A General Framework for Assessing In vitro/In vivo Correlation as a Tool for Maximizing the Benefit‐Risk Ratio of a Treatment Using a Convolution‐Based Modeling Approach

The net benefit of a treatment can be defined by the relationship between clinical improvement and risk of adverse events: the benefit‐risk ratio. The optimization of the benefit‐risk ratio can be achieved by identifying the most adequate dose (and/or dosage regimen) jointly with the best‐performing...

Descripción completa

Detalles Bibliográficos
Autores principales: Gomeni, Roberto, Fang, Lanyan (Lucy), Bressolle‐Gomeni, Françoise, Spencer, Thomas J., Faraone, Stephen V., Babiskin, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389349/
https://www.ncbi.nlm.nih.gov/pubmed/30659771
http://dx.doi.org/10.1002/psp4.12378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389349/
https://www.ncbi.nlm.nih.gov/pubmed/30659771
http://dx.doi.org/10.1002/psp4.12378

Ejemplares similares