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Genome-Wide CRISPR Screening Identifies JAK1 Deficiency as a Mechanism of T-Cell Resistance

Somatic gene mutations play a critical role in immune evasion by tumors. However, there is limited information on genes that confer immunotherapy resistance in melanoma. To answer this question, we established a whole-genome knockout B16/ovalbumin cell line by clustered regularly interspaced short p...

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Detalles Bibliográficos
Autores principales:	Han, Ping, Dai, Qiang, Fan, Lilv, Lin, Hao, Zhang, Xiaoqing, Li, Fanlin, Yang, Xuanming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389627/ https://www.ncbi.nlm.nih.gov/pubmed/30837996 http://dx.doi.org/10.3389/fimmu.2019.00251

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