Mutations in Efflux Pump Rv1258c (Tap) Cause Resistance to Pyrazinamide, Isoniazid, and Streptomycin in M. tuberculosis

Although drug resistance in Mycobacterium tuberculosis is mainly caused by mutations in drug activating enzymes or drug targets, there is increasing interest in the possible role of efflux in causing drug resistance. Previously, efflux genes have been shown to be upregulated upon drug exposure or im...

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Detalles Bibliográficos
Autores principales: Liu, Jiayun, Shi, Wanliang, Zhang, Shuo, Hao, Xiaoke, Maslov, Dmitry A., Shur, Kirill V., Bekker, Olga B., Danilenko, Valery N., Zhang, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389670/
https://www.ncbi.nlm.nih.gov/pubmed/30837962
http://dx.doi.org/10.3389/fmicb.2019.00216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389670/
https://www.ncbi.nlm.nih.gov/pubmed/30837962
http://dx.doi.org/10.3389/fmicb.2019.00216

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