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CFTR dysfunction increases endoglin and TGF‐β signaling in airway epithelia

Endoglin (ENG) regulates signaling by transforming growth factor‐β (TGF‐β), a genetic modifier of cystic fibrosis (CF) lung disease severity. We hypothesized that ENG mediates TGF‐β pathobiology in CF airway epithelia. Comparing CF and non‐CF human lungs, we measured ENG by qPCR, immunoblotting and...

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Detalles Bibliográficos
Autores principales:	Nicola, Teodora, Kabir, Farruk L., Coric, Tatjana, Wall, Stephanie B., Zhang, Weifeng, James, Masheika, MacEwen, Mark, Ren, Changchun, Halloran, Brian, Ambalavanan, Namasivayam, Harris, William T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389738/ https://www.ncbi.nlm.nih.gov/pubmed/30806029 http://dx.doi.org/10.14814/phy2.13977

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