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Longitudinal advanced MRI case report of white matter radiation necrosis
Radiation necrosis mostly occurs in and near the radiation field. We used magnetic resonance imaging to study radiation‐induced necrosis of atypical onset, severity, and extent following stereotactic radiosurgery for a symptomatic arteriovenous malformation. Susceptibility‐sensitive imaging, T(1)‐re...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389755/ https://www.ncbi.nlm.nih.gov/pubmed/30847370 http://dx.doi.org/10.1002/acn3.704 |
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author | Wiggermann, Vanessa Lapointe, Emmanuelle Litvin, Ludmila Graf, Carina Hernández‐Torres, Enedino McKenzie, Michael Vavasour, Irene M. Laule, Cornelia MacMillan, Erin L. Li, David K. B. Kolind, Shannon H. Rauscher, Alexander Traboulsee, Anthony L. |
author_facet | Wiggermann, Vanessa Lapointe, Emmanuelle Litvin, Ludmila Graf, Carina Hernández‐Torres, Enedino McKenzie, Michael Vavasour, Irene M. Laule, Cornelia MacMillan, Erin L. Li, David K. B. Kolind, Shannon H. Rauscher, Alexander Traboulsee, Anthony L. |
author_sort | Wiggermann, Vanessa |
collection | PubMed |
description | Radiation necrosis mostly occurs in and near the radiation field. We used magnetic resonance imaging to study radiation‐induced necrosis of atypical onset, severity, and extent following stereotactic radiosurgery for a symptomatic arteriovenous malformation. Susceptibility‐sensitive imaging, T(1)‐relaxation, myelin water imaging, and magnetic resonance spectroscopy were acquired three times up to 52 months postradiosurgery. Increasing water content outside the radiation field, contralateral neuronal loss, and gliosis were detected over time. Our findings suggest that radiation‐induced vasculopathic changes spread more diffusely than previously described. An autoimmune response to brain antigens could underlie white matter changes outside the initial radiation field. |
format | Online Article Text |
id | pubmed-6389755 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63897552019-03-07 Longitudinal advanced MRI case report of white matter radiation necrosis Wiggermann, Vanessa Lapointe, Emmanuelle Litvin, Ludmila Graf, Carina Hernández‐Torres, Enedino McKenzie, Michael Vavasour, Irene M. Laule, Cornelia MacMillan, Erin L. Li, David K. B. Kolind, Shannon H. Rauscher, Alexander Traboulsee, Anthony L. Ann Clin Transl Neurol Brief Communications Radiation necrosis mostly occurs in and near the radiation field. We used magnetic resonance imaging to study radiation‐induced necrosis of atypical onset, severity, and extent following stereotactic radiosurgery for a symptomatic arteriovenous malformation. Susceptibility‐sensitive imaging, T(1)‐relaxation, myelin water imaging, and magnetic resonance spectroscopy were acquired three times up to 52 months postradiosurgery. Increasing water content outside the radiation field, contralateral neuronal loss, and gliosis were detected over time. Our findings suggest that radiation‐induced vasculopathic changes spread more diffusely than previously described. An autoimmune response to brain antigens could underlie white matter changes outside the initial radiation field. John Wiley and Sons Inc. 2018-12-10 /pmc/articles/PMC6389755/ /pubmed/30847370 http://dx.doi.org/10.1002/acn3.704 Text en © 2018 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Brief Communications Wiggermann, Vanessa Lapointe, Emmanuelle Litvin, Ludmila Graf, Carina Hernández‐Torres, Enedino McKenzie, Michael Vavasour, Irene M. Laule, Cornelia MacMillan, Erin L. Li, David K. B. Kolind, Shannon H. Rauscher, Alexander Traboulsee, Anthony L. Longitudinal advanced MRI case report of white matter radiation necrosis |
title | Longitudinal advanced MRI case report of white matter radiation necrosis |
title_full | Longitudinal advanced MRI case report of white matter radiation necrosis |
title_fullStr | Longitudinal advanced MRI case report of white matter radiation necrosis |
title_full_unstemmed | Longitudinal advanced MRI case report of white matter radiation necrosis |
title_short | Longitudinal advanced MRI case report of white matter radiation necrosis |
title_sort | longitudinal advanced mri case report of white matter radiation necrosis |
topic | Brief Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389755/ https://www.ncbi.nlm.nih.gov/pubmed/30847370 http://dx.doi.org/10.1002/acn3.704 |
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