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Isothermal Analysis of ThermoFluor Data can readily provide Quantitative Binding Affinities
Differential scanning fluorimetry (DSF), also known as ThermoFluor or Thermal Shift Assay, has become a commonly-used approach for detecting protein-ligand interactions, particularly in the context of fragment screening. Upon binding to a folded protein, most ligands stabilize the protein; thus, obs...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389909/ https://www.ncbi.nlm.nih.gov/pubmed/30804351 http://dx.doi.org/10.1038/s41598-018-37072-x |