Altered splicing and cytoplasmic levels of tRNA synthetases in SF3B1-mutant myelodysplastic syndromes as a therapeutic vulnerability

Myelodysplastic syndromes (MDS) are haematopoietic malignancies that are characterised by a heterogeneous clinical course. In recent years, sequencing efforts have uncovered recurrent somatic mutations within RNA splicing factors, including SF3B1, SRSF2, U2AF1 and ZRSR2. The most frequently mutated...

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Detalles Bibliográficos
Autores principales: Liberante, Fabio Giuseppe, Lappin, Katrina, Barros, Eliana M., Vohhodina, Jekaterina, Grebien, Florian, Savage, Kienan I., Mills, Kenneth Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390101/
https://www.ncbi.nlm.nih.gov/pubmed/30804405
http://dx.doi.org/10.1038/s41598-019-39591-7

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