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Serum Iron Metabolism Variables in Clinically Healthy Persons

BACKGROUND: In healthy persons, iron acquisition, trafficking and storage are strictly regulated processes due to the lack of a physiological pathway for the excretion of excess iron from the body. The liver, the duodenum and the bone marrow are involved in the regulation of iron metabolism. MATERIA...

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Autores principales: Penkova, Mariana, Ivanova, Nadezhda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Republic of Macedonia 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390146/
https://www.ncbi.nlm.nih.gov/pubmed/30833994
http://dx.doi.org/10.3889/oamjms.2019.083
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author Penkova, Mariana
Ivanova, Nadezhda
author_facet Penkova, Mariana
Ivanova, Nadezhda
author_sort Penkova, Mariana
collection PubMed
description BACKGROUND: In healthy persons, iron acquisition, trafficking and storage are strictly regulated processes due to the lack of a physiological pathway for the excretion of excess iron from the body. The liver, the duodenum and the bone marrow are involved in the regulation of iron metabolism. MATERIAL: Subject to the testing were 60 healthy volunteers who took part in clinical trials. METHODS: Case histories, physical check-up and demographic data including people’s heights and weights, laboratory studies and tests using medical equipment. RESULTS: None of the healthy persons were reported to have shown any deviation from the reference values for the serum markers of iron metabolism tested with the exception of hepcidin. CONCLUSION: In healthy persons, there was only a positive correlation between iron level and IBC, and feedback between hepcidin serum levels and transferrin saturation.
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spelling pubmed-63901462019-03-04 Serum Iron Metabolism Variables in Clinically Healthy Persons Penkova, Mariana Ivanova, Nadezhda Open Access Maced J Med Sci Basic Science BACKGROUND: In healthy persons, iron acquisition, trafficking and storage are strictly regulated processes due to the lack of a physiological pathway for the excretion of excess iron from the body. The liver, the duodenum and the bone marrow are involved in the regulation of iron metabolism. MATERIAL: Subject to the testing were 60 healthy volunteers who took part in clinical trials. METHODS: Case histories, physical check-up and demographic data including people’s heights and weights, laboratory studies and tests using medical equipment. RESULTS: None of the healthy persons were reported to have shown any deviation from the reference values for the serum markers of iron metabolism tested with the exception of hepcidin. CONCLUSION: In healthy persons, there was only a positive correlation between iron level and IBC, and feedback between hepcidin serum levels and transferrin saturation. Republic of Macedonia 2019-02-07 /pmc/articles/PMC6390146/ /pubmed/30833994 http://dx.doi.org/10.3889/oamjms.2019.083 Text en Copyright: © 2019 Mariana Penkova, Nadezhda Ivanova http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
spellingShingle Basic Science
Penkova, Mariana
Ivanova, Nadezhda
Serum Iron Metabolism Variables in Clinically Healthy Persons
title Serum Iron Metabolism Variables in Clinically Healthy Persons
title_full Serum Iron Metabolism Variables in Clinically Healthy Persons
title_fullStr Serum Iron Metabolism Variables in Clinically Healthy Persons
title_full_unstemmed Serum Iron Metabolism Variables in Clinically Healthy Persons
title_short Serum Iron Metabolism Variables in Clinically Healthy Persons
title_sort serum iron metabolism variables in clinically healthy persons
topic Basic Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390146/
https://www.ncbi.nlm.nih.gov/pubmed/30833994
http://dx.doi.org/10.3889/oamjms.2019.083
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