Cargando…
Preliminary Neurophysiological Evidence of Altered Cortical Activity and Connectivity With Neurologic Music Therapy in Parkinson's Disease
Neurologic Music Therapy (NMT) is a novel impairment-focused behavioral intervention system whose techniques are based on the clinical neuroscience of music perception, cognition, and production. Auditory Stimulation (RAS) is one of the NMT techniques, which aims to develop and maintain a physiologi...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390231/ https://www.ncbi.nlm.nih.gov/pubmed/30837830 http://dx.doi.org/10.3389/fnins.2019.00105 |
_version_ | 1783398102790569984 |
---|---|
author | Buard, Isabelle Dewispelaere, William B. Thaut, Michael Kluger, Benzi M. |
author_facet | Buard, Isabelle Dewispelaere, William B. Thaut, Michael Kluger, Benzi M. |
author_sort | Buard, Isabelle |
collection | PubMed |
description | Neurologic Music Therapy (NMT) is a novel impairment-focused behavioral intervention system whose techniques are based on the clinical neuroscience of music perception, cognition, and production. Auditory Stimulation (RAS) is one of the NMT techniques, which aims to develop and maintain a physiological rhythmic motor activity through rhythmic auditory cues. In a series of breakthrough studies beginning in the mid-nineties, we discovered that RAS durably improves gait velocity, stride length, and cadence in Parkinson's disease (PD). No study to date reports the neurophysiological evidence of auditory-motor frequency entrainment after a NMT intervention in the Parkinson's community. We hypothesized that NMT-related motor improvements in PD are due to entrainment-related coupling between auditory and motor activity resulting from an increased functional communication between the auditory and the motor cortices. Spectral analysis in the primary motor and auditory cortices during a cued finger tapping task showed a simultaneous increase in evoked power in the beta-range along with an increased functional connectivity after a course of NMT in a small sample of three older adults with PD. This case study provides preliminary evidence that NMT-based motor rehabilitation may enhance cortical activation in the auditory and motor areas in a synergic manner. With a lack of both control subjects and control conditions, this neuroimaging case-proof of concept series of visible changes suggests potential mechanisms and offers further education on the clinical applications of musical interventions for motor impairments. |
format | Online Article Text |
id | pubmed-6390231 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63902312019-03-05 Preliminary Neurophysiological Evidence of Altered Cortical Activity and Connectivity With Neurologic Music Therapy in Parkinson's Disease Buard, Isabelle Dewispelaere, William B. Thaut, Michael Kluger, Benzi M. Front Neurosci Neuroscience Neurologic Music Therapy (NMT) is a novel impairment-focused behavioral intervention system whose techniques are based on the clinical neuroscience of music perception, cognition, and production. Auditory Stimulation (RAS) is one of the NMT techniques, which aims to develop and maintain a physiological rhythmic motor activity through rhythmic auditory cues. In a series of breakthrough studies beginning in the mid-nineties, we discovered that RAS durably improves gait velocity, stride length, and cadence in Parkinson's disease (PD). No study to date reports the neurophysiological evidence of auditory-motor frequency entrainment after a NMT intervention in the Parkinson's community. We hypothesized that NMT-related motor improvements in PD are due to entrainment-related coupling between auditory and motor activity resulting from an increased functional communication between the auditory and the motor cortices. Spectral analysis in the primary motor and auditory cortices during a cued finger tapping task showed a simultaneous increase in evoked power in the beta-range along with an increased functional connectivity after a course of NMT in a small sample of three older adults with PD. This case study provides preliminary evidence that NMT-based motor rehabilitation may enhance cortical activation in the auditory and motor areas in a synergic manner. With a lack of both control subjects and control conditions, this neuroimaging case-proof of concept series of visible changes suggests potential mechanisms and offers further education on the clinical applications of musical interventions for motor impairments. Frontiers Media S.A. 2019-02-19 /pmc/articles/PMC6390231/ /pubmed/30837830 http://dx.doi.org/10.3389/fnins.2019.00105 Text en Copyright © 2019 Buard, Dewispelaere, Thaut and Kluger. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Buard, Isabelle Dewispelaere, William B. Thaut, Michael Kluger, Benzi M. Preliminary Neurophysiological Evidence of Altered Cortical Activity and Connectivity With Neurologic Music Therapy in Parkinson's Disease |
title | Preliminary Neurophysiological Evidence of Altered Cortical Activity and Connectivity With Neurologic Music Therapy in Parkinson's Disease |
title_full | Preliminary Neurophysiological Evidence of Altered Cortical Activity and Connectivity With Neurologic Music Therapy in Parkinson's Disease |
title_fullStr | Preliminary Neurophysiological Evidence of Altered Cortical Activity and Connectivity With Neurologic Music Therapy in Parkinson's Disease |
title_full_unstemmed | Preliminary Neurophysiological Evidence of Altered Cortical Activity and Connectivity With Neurologic Music Therapy in Parkinson's Disease |
title_short | Preliminary Neurophysiological Evidence of Altered Cortical Activity and Connectivity With Neurologic Music Therapy in Parkinson's Disease |
title_sort | preliminary neurophysiological evidence of altered cortical activity and connectivity with neurologic music therapy in parkinson's disease |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390231/ https://www.ncbi.nlm.nih.gov/pubmed/30837830 http://dx.doi.org/10.3389/fnins.2019.00105 |
work_keys_str_mv | AT buardisabelle preliminaryneurophysiologicalevidenceofalteredcorticalactivityandconnectivitywithneurologicmusictherapyinparkinsonsdisease AT dewispelaerewilliamb preliminaryneurophysiologicalevidenceofalteredcorticalactivityandconnectivitywithneurologicmusictherapyinparkinsonsdisease AT thautmichael preliminaryneurophysiologicalevidenceofalteredcorticalactivityandconnectivitywithneurologicmusictherapyinparkinsonsdisease AT klugerbenzim preliminaryneurophysiologicalevidenceofalteredcorticalactivityandconnectivitywithneurologicmusictherapyinparkinsonsdisease |