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Stem cells: past, present, and future
In recent years, stem cell therapy has become a very promising and advanced scientific research topic. The development of treatment methods has evoked great expectations. This paper is a review focused on the discovery of different stem cells and the potential therapies based on these cells. The gen...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390367/ https://www.ncbi.nlm.nih.gov/pubmed/30808416 http://dx.doi.org/10.1186/s13287-019-1165-5 |
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author | Zakrzewski, Wojciech Dobrzyński, Maciej Szymonowicz, Maria Rybak, Zbigniew |
author_facet | Zakrzewski, Wojciech Dobrzyński, Maciej Szymonowicz, Maria Rybak, Zbigniew |
author_sort | Zakrzewski, Wojciech |
collection | PubMed |
description | In recent years, stem cell therapy has become a very promising and advanced scientific research topic. The development of treatment methods has evoked great expectations. This paper is a review focused on the discovery of different stem cells and the potential therapies based on these cells. The genesis of stem cells is followed by laboratory steps of controlled stem cell culturing and derivation. Quality control and teratoma formation assays are important procedures in assessing the properties of the stem cells tested. Derivation methods and the utilization of culturing media are crucial to set proper environmental conditions for controlled differentiation. Among many types of stem tissue applications, the use of graphene scaffolds and the potential of extracellular vesicle-based therapies require attention due to their versatility. The review is summarized by challenges that stem cell therapy must overcome to be accepted worldwide. A wide variety of possibilities makes this cutting edge therapy a turning point in modern medicine, providing hope for untreatable diseases. |
format | Online Article Text |
id | pubmed-6390367 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-63903672019-03-19 Stem cells: past, present, and future Zakrzewski, Wojciech Dobrzyński, Maciej Szymonowicz, Maria Rybak, Zbigniew Stem Cell Res Ther Review In recent years, stem cell therapy has become a very promising and advanced scientific research topic. The development of treatment methods has evoked great expectations. This paper is a review focused on the discovery of different stem cells and the potential therapies based on these cells. The genesis of stem cells is followed by laboratory steps of controlled stem cell culturing and derivation. Quality control and teratoma formation assays are important procedures in assessing the properties of the stem cells tested. Derivation methods and the utilization of culturing media are crucial to set proper environmental conditions for controlled differentiation. Among many types of stem tissue applications, the use of graphene scaffolds and the potential of extracellular vesicle-based therapies require attention due to their versatility. The review is summarized by challenges that stem cell therapy must overcome to be accepted worldwide. A wide variety of possibilities makes this cutting edge therapy a turning point in modern medicine, providing hope for untreatable diseases. BioMed Central 2019-02-26 /pmc/articles/PMC6390367/ /pubmed/30808416 http://dx.doi.org/10.1186/s13287-019-1165-5 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Zakrzewski, Wojciech Dobrzyński, Maciej Szymonowicz, Maria Rybak, Zbigniew Stem cells: past, present, and future |
title | Stem cells: past, present, and future |
title_full | Stem cells: past, present, and future |
title_fullStr | Stem cells: past, present, and future |
title_full_unstemmed | Stem cells: past, present, and future |
title_short | Stem cells: past, present, and future |
title_sort | stem cells: past, present, and future |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390367/ https://www.ncbi.nlm.nih.gov/pubmed/30808416 http://dx.doi.org/10.1186/s13287-019-1165-5 |
work_keys_str_mv | AT zakrzewskiwojciech stemcellspastpresentandfuture AT dobrzynskimaciej stemcellspastpresentandfuture AT szymonowiczmaria stemcellspastpresentandfuture AT rybakzbigniew stemcellspastpresentandfuture |