Co-delivery of Cisplatin(IV) and Capecitabine as an Effective and Non-toxic Cancer Treatment

A strategy for preparing composite micelles (CM) containing both cisplatin(IV) [CisPt(IV)] prodrug and capecitabine using a co-assembly method is described in this study. The CM are capable of an effective release of the anticancer drug cisplatin(II) [CisPt(II)] and capecitabine via acid hydrolysis...

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Autores principales: Xiao, Xiao, Wang, Ting, Li, Leijiao, Zhu, Zhongli, Zhang, Weina, Cui, Guihua, Li, Wenliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390499/
https://www.ncbi.nlm.nih.gov/pubmed/30837877
http://dx.doi.org/10.3389/fphar.2019.00110
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author Xiao, Xiao
Wang, Ting
Li, Leijiao
Zhu, Zhongli
Zhang, Weina
Cui, Guihua
Li, Wenliang
author_facet Xiao, Xiao
Wang, Ting
Li, Leijiao
Zhu, Zhongli
Zhang, Weina
Cui, Guihua
Li, Wenliang
author_sort Xiao, Xiao
collection PubMed
description A strategy for preparing composite micelles (CM) containing both cisplatin(IV) [CisPt(IV)] prodrug and capecitabine using a co-assembly method is described in this study. The CM are capable of an effective release of the anticancer drug cisplatin(II) [CisPt(II)] and capecitabine via acid hydrolysis once they are internalized by cancer cells. Moreover, the CM display a synergistic effect in vitro and the combination therapy in the micellar dosage form leads to reduced systemic toxicity and enhanced antitumor efficacy in vivo.
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spelling pubmed-63904992019-03-05 Co-delivery of Cisplatin(IV) and Capecitabine as an Effective and Non-toxic Cancer Treatment Xiao, Xiao Wang, Ting Li, Leijiao Zhu, Zhongli Zhang, Weina Cui, Guihua Li, Wenliang Front Pharmacol Pharmacology A strategy for preparing composite micelles (CM) containing both cisplatin(IV) [CisPt(IV)] prodrug and capecitabine using a co-assembly method is described in this study. The CM are capable of an effective release of the anticancer drug cisplatin(II) [CisPt(II)] and capecitabine via acid hydrolysis once they are internalized by cancer cells. Moreover, the CM display a synergistic effect in vitro and the combination therapy in the micellar dosage form leads to reduced systemic toxicity and enhanced antitumor efficacy in vivo. Frontiers Media S.A. 2019-02-19 /pmc/articles/PMC6390499/ /pubmed/30837877 http://dx.doi.org/10.3389/fphar.2019.00110 Text en Copyright © 2019 Xiao, Wang, Li, Zhu, Zhang, Cui and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Xiao, Xiao
Wang, Ting
Li, Leijiao
Zhu, Zhongli
Zhang, Weina
Cui, Guihua
Li, Wenliang
Co-delivery of Cisplatin(IV) and Capecitabine as an Effective and Non-toxic Cancer Treatment
title Co-delivery of Cisplatin(IV) and Capecitabine as an Effective and Non-toxic Cancer Treatment
title_full Co-delivery of Cisplatin(IV) and Capecitabine as an Effective and Non-toxic Cancer Treatment
title_fullStr Co-delivery of Cisplatin(IV) and Capecitabine as an Effective and Non-toxic Cancer Treatment
title_full_unstemmed Co-delivery of Cisplatin(IV) and Capecitabine as an Effective and Non-toxic Cancer Treatment
title_short Co-delivery of Cisplatin(IV) and Capecitabine as an Effective and Non-toxic Cancer Treatment
title_sort co-delivery of cisplatin(iv) and capecitabine as an effective and non-toxic cancer treatment
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390499/
https://www.ncbi.nlm.nih.gov/pubmed/30837877
http://dx.doi.org/10.3389/fphar.2019.00110
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