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Detecting amino acid preference shifts with codon-level mutation-selection mixture models

BACKGROUND: In recent years, increasing attention has been placed on the development of phylogeny-based statistical methodologies for uncovering site-specific changes in amino acid fitness profiles over time. The few available random-effects approaches, modelling across-site variation in amino acid...

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Detalles Bibliográficos
Autores principales:	Kazmi, S. Omar, Rodrigue, Nicolas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Methodology Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390532/ https://www.ncbi.nlm.nih.gov/pubmed/30808289 http://dx.doi.org/10.1186/s12862-019-1358-7

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