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Wild type p53 function in p53(Y220C) mutant harboring cells by treatment with Ashwagandha derived anticancer withanolides: bioinformatics and experimental evidence

BACKGROUND: Tumor suppressor p53 protein is frequently mutated in a large majority of cancers. These mutations induce local or global changes in protein structure thereby affecting its binding to DNA. The structural differences between the wild type and mutant p53 thus provide an opportunity to sele...

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Detalles Bibliográficos
Autores principales:	Sundar, Durai, Yu, Yue, Katiyar, Shashank P., Putri, Jayarani F., Dhanjal, Jaspreet Kaur, Wang, Jia, Sari, Anissa Nofita, Kolettas, Evangelos, Kaul, Sunil C., Wadhwa, Renu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390572/ https://www.ncbi.nlm.nih.gov/pubmed/30808373 http://dx.doi.org/10.1186/s13046-019-1099-x

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