Therapeutic effect of palbociclib in chondrosarcoma: implication of cyclin-dependent kinase 4 as a potential target

BACKGROUND: Chondrosarcoma is a malignant cartilaginous neoplasm of the bone which resistant to radiation therapy and chemotherapy. Cyclin-dependent kinase 4 (CKD4) is highly expressed in human cancer, and palbociclib, the inhibitor of CDK4 has been used clinically under FDA approval for application...

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Detalles Bibliográficos
Autores principales: Ouyang, Zhengxiao, Wang, Sisi, Zeng, Ming, Li, Zhihong, Zhang, Qing, Wang, Wanchun, Liu, Tang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390580/
https://www.ncbi.nlm.nih.gov/pubmed/30808351
http://dx.doi.org/10.1186/s12964-019-0327-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390580/
https://www.ncbi.nlm.nih.gov/pubmed/30808351
http://dx.doi.org/10.1186/s12964-019-0327-5

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