Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naïve lung adenocarcinoma

BACKGROUND: In lung cancer, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor sensitizing mutations co-existing with rare minor EGFR mutations are known as compound mutations. These minor EGFR mutations can lead to acquired resistance after EGFR tyrosine kinase inhibitor treatment, s...

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Detalles Bibliográficos
Autores principales: Namba, Kei, Tomida, Shuta, Matsubara, Takehiro, Takahashi, Yuta, Kurihara, Eisuke, Ogoshi, Yusuke, Yoshioka, Takahiro, Takeda, Tatsuaki, Torigoe, Hidejiro, Sato, Hiroki, Shien, Kazuhiko, Yamamoto, Hiromasa, Soh, Junichi, Tsukuda, Kazunori, Toyooka, Shinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390598/
https://www.ncbi.nlm.nih.gov/pubmed/30808329
http://dx.doi.org/10.1186/s12885-019-5374-1

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