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Neutrophil Subsets, Platelets, and Vascular Disease in Psoriasis
Psoriasis is an inflammatory skin disease associated with increased cardiovascular risk and serves as a reliable model to study inflammatory atherogenesis. Because neutrophils are implicated in atherosclerosis development, this study reports that the interaction among low-density granulocytes, a sub...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390681/ https://www.ncbi.nlm.nih.gov/pubmed/30847414 http://dx.doi.org/10.1016/j.jacbts.2018.10.008 |
| _version_ | 1783398187749343232 |
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| author | Teague, Heather L. Varghese, Nevin J. Tsoi, Lam C. Dey, Amit K. Garshick, Michael S. Silverman, Joanna I. Baumer, Yvonne Harrington, Charlotte L. Stempinski, Erin Elnabawi, Youssef A. Dagur, Pradeep K. Cui, Kairong Tunc, Ilker Seifuddin, Fayaz Joshi, Aditya A. Stansky, Elena Purmalek, Monica M. Rodante, Justin A. Keel, Andrew Aridi, Tarek Z. Carmona-Rivera, Carmelo Sanda, Gregory E. Chen, Marcus Y. Pirooznia, Mehdi McCoy, J. Philip Gelfand, Joel M. Zhao, Keji Gudjonsson, Johann E. Playford, Martin P. Kaplan, Mariana J. Berger, Jeffrey S. Mehta, Nehal N. |
| author_facet | Teague, Heather L. Varghese, Nevin J. Tsoi, Lam C. Dey, Amit K. Garshick, Michael S. Silverman, Joanna I. Baumer, Yvonne Harrington, Charlotte L. Stempinski, Erin Elnabawi, Youssef A. Dagur, Pradeep K. Cui, Kairong Tunc, Ilker Seifuddin, Fayaz Joshi, Aditya A. Stansky, Elena Purmalek, Monica M. Rodante, Justin A. Keel, Andrew Aridi, Tarek Z. Carmona-Rivera, Carmelo Sanda, Gregory E. Chen, Marcus Y. Pirooznia, Mehdi McCoy, J. Philip Gelfand, Joel M. Zhao, Keji Gudjonsson, Johann E. Playford, Martin P. Kaplan, Mariana J. Berger, Jeffrey S. Mehta, Nehal N. |
| author_sort | Teague, Heather L. |
| collection | PubMed |
| description | Psoriasis is an inflammatory skin disease associated with increased cardiovascular risk and serves as a reliable model to study inflammatory atherogenesis. Because neutrophils are implicated in atherosclerosis development, this study reports that the interaction among low-density granulocytes, a subset of neutrophils, and platelets is associated with a noncalcified coronary plaque burden assessed by coronary computed tomography angiography. Because early atherosclerotic noncalcified burden can lead to fatal myocardial infarction, the low-density granulocyte−platelet interaction may play a crucial target for clinical intervention. |
| format | Online Article Text |
| id | pubmed-6390681 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-63906812019-03-07 Neutrophil Subsets, Platelets, and Vascular Disease in Psoriasis Teague, Heather L. Varghese, Nevin J. Tsoi, Lam C. Dey, Amit K. Garshick, Michael S. Silverman, Joanna I. Baumer, Yvonne Harrington, Charlotte L. Stempinski, Erin Elnabawi, Youssef A. Dagur, Pradeep K. Cui, Kairong Tunc, Ilker Seifuddin, Fayaz Joshi, Aditya A. Stansky, Elena Purmalek, Monica M. Rodante, Justin A. Keel, Andrew Aridi, Tarek Z. Carmona-Rivera, Carmelo Sanda, Gregory E. Chen, Marcus Y. Pirooznia, Mehdi McCoy, J. Philip Gelfand, Joel M. Zhao, Keji Gudjonsson, Johann E. Playford, Martin P. Kaplan, Mariana J. Berger, Jeffrey S. Mehta, Nehal N. JACC Basic Transl Sci LEADING EDGE TRANSLATIONAL RESEARCH Psoriasis is an inflammatory skin disease associated with increased cardiovascular risk and serves as a reliable model to study inflammatory atherogenesis. Because neutrophils are implicated in atherosclerosis development, this study reports that the interaction among low-density granulocytes, a subset of neutrophils, and platelets is associated with a noncalcified coronary plaque burden assessed by coronary computed tomography angiography. Because early atherosclerotic noncalcified burden can lead to fatal myocardial infarction, the low-density granulocyte−platelet interaction may play a crucial target for clinical intervention. Elsevier 2019-02-25 /pmc/articles/PMC6390681/ /pubmed/30847414 http://dx.doi.org/10.1016/j.jacbts.2018.10.008 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | LEADING EDGE TRANSLATIONAL RESEARCH Teague, Heather L. Varghese, Nevin J. Tsoi, Lam C. Dey, Amit K. Garshick, Michael S. Silverman, Joanna I. Baumer, Yvonne Harrington, Charlotte L. Stempinski, Erin Elnabawi, Youssef A. Dagur, Pradeep K. Cui, Kairong Tunc, Ilker Seifuddin, Fayaz Joshi, Aditya A. Stansky, Elena Purmalek, Monica M. Rodante, Justin A. Keel, Andrew Aridi, Tarek Z. Carmona-Rivera, Carmelo Sanda, Gregory E. Chen, Marcus Y. Pirooznia, Mehdi McCoy, J. Philip Gelfand, Joel M. Zhao, Keji Gudjonsson, Johann E. Playford, Martin P. Kaplan, Mariana J. Berger, Jeffrey S. Mehta, Nehal N. Neutrophil Subsets, Platelets, and Vascular Disease in Psoriasis |
| title | Neutrophil Subsets, Platelets, and Vascular Disease in Psoriasis |
| title_full | Neutrophil Subsets, Platelets, and Vascular Disease in Psoriasis |
| title_fullStr | Neutrophil Subsets, Platelets, and Vascular Disease in Psoriasis |
| title_full_unstemmed | Neutrophil Subsets, Platelets, and Vascular Disease in Psoriasis |
| title_short | Neutrophil Subsets, Platelets, and Vascular Disease in Psoriasis |
| title_sort | neutrophil subsets, platelets, and vascular disease in psoriasis |
| topic | LEADING EDGE TRANSLATIONAL RESEARCH |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390681/ https://www.ncbi.nlm.nih.gov/pubmed/30847414 http://dx.doi.org/10.1016/j.jacbts.2018.10.008 |
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