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Epidemiology of Extrapulmonary Tuberculosis among Inpatients, China, 2008–2017

We investigated the epidemiology of extrapulmonary tuberculosis (TB) among patients admitted to Beijing Chest Hospital, Beijing, China, during January 2008–December 2017. Of 19,279 hospitalized TB patients, 33.4% (6,433) had extrapulmonary TB and 66.6% (12,846) had pulmonary TB. The most frequent fo...

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Autores principales: Pang, Yu, An, Jun, Shu, Wei, Huo, Fengmin, Chu, Naihui, Gao, Mengqiu, Qin, Shibing, Huang, Hairong, Chen, Xiaoyou, Xu, Shaofa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390737/
https://www.ncbi.nlm.nih.gov/pubmed/30789144
http://dx.doi.org/10.3201/eid2503.180572
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author Pang, Yu
An, Jun
Shu, Wei
Huo, Fengmin
Chu, Naihui
Gao, Mengqiu
Qin, Shibing
Huang, Hairong
Chen, Xiaoyou
Xu, Shaofa
author_facet Pang, Yu
An, Jun
Shu, Wei
Huo, Fengmin
Chu, Naihui
Gao, Mengqiu
Qin, Shibing
Huang, Hairong
Chen, Xiaoyou
Xu, Shaofa
author_sort Pang, Yu
collection PubMed
description We investigated the epidemiology of extrapulmonary tuberculosis (TB) among patients admitted to Beijing Chest Hospital, Beijing, China, during January 2008–December 2017. Of 19,279 hospitalized TB patients, 33.4% (6,433) had extrapulmonary TB and 66.6% (12,846) had pulmonary TB. The most frequent forms of extrapulmonary TB observed were skeletal TB (41.1%) and pleural TB (26.0%). Younger, female patients from rural areas were more likely to have extrapulmonary TB. However, patients with diabetes mellitus were less likely to have extrapulmonary TB compared with patients without diabetes. A higher proportion of multidrug-resistant (MDR) TB was observed among patients with extrapulmonary TB than among patients with pulmonary TB. We observed a large increase in MDR TB, from 17.3% to 35.7%, for pleural TB cases. The increasing rate of drug resistance among extrapulmonary TB cases highlights the need for drug susceptibility testing and the formulation of more effective regimens for extrapulmonary TB treatment.
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spelling pubmed-63907372019-03-06 Epidemiology of Extrapulmonary Tuberculosis among Inpatients, China, 2008–2017 Pang, Yu An, Jun Shu, Wei Huo, Fengmin Chu, Naihui Gao, Mengqiu Qin, Shibing Huang, Hairong Chen, Xiaoyou Xu, Shaofa Emerg Infect Dis Synopsis We investigated the epidemiology of extrapulmonary tuberculosis (TB) among patients admitted to Beijing Chest Hospital, Beijing, China, during January 2008–December 2017. Of 19,279 hospitalized TB patients, 33.4% (6,433) had extrapulmonary TB and 66.6% (12,846) had pulmonary TB. The most frequent forms of extrapulmonary TB observed were skeletal TB (41.1%) and pleural TB (26.0%). Younger, female patients from rural areas were more likely to have extrapulmonary TB. However, patients with diabetes mellitus were less likely to have extrapulmonary TB compared with patients without diabetes. A higher proportion of multidrug-resistant (MDR) TB was observed among patients with extrapulmonary TB than among patients with pulmonary TB. We observed a large increase in MDR TB, from 17.3% to 35.7%, for pleural TB cases. The increasing rate of drug resistance among extrapulmonary TB cases highlights the need for drug susceptibility testing and the formulation of more effective regimens for extrapulmonary TB treatment. Centers for Disease Control and Prevention 2019-03 /pmc/articles/PMC6390737/ /pubmed/30789144 http://dx.doi.org/10.3201/eid2503.180572 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Synopsis
Pang, Yu
An, Jun
Shu, Wei
Huo, Fengmin
Chu, Naihui
Gao, Mengqiu
Qin, Shibing
Huang, Hairong
Chen, Xiaoyou
Xu, Shaofa
Epidemiology of Extrapulmonary Tuberculosis among Inpatients, China, 2008–2017
title Epidemiology of Extrapulmonary Tuberculosis among Inpatients, China, 2008–2017
title_full Epidemiology of Extrapulmonary Tuberculosis among Inpatients, China, 2008–2017
title_fullStr Epidemiology of Extrapulmonary Tuberculosis among Inpatients, China, 2008–2017
title_full_unstemmed Epidemiology of Extrapulmonary Tuberculosis among Inpatients, China, 2008–2017
title_short Epidemiology of Extrapulmonary Tuberculosis among Inpatients, China, 2008–2017
title_sort epidemiology of extrapulmonary tuberculosis among inpatients, china, 2008–2017
topic Synopsis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390737/
https://www.ncbi.nlm.nih.gov/pubmed/30789144
http://dx.doi.org/10.3201/eid2503.180572
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