Whole-Genome Sequencing of Drug-Resistant Mycobacterium tuberculosis Strains, Tunisia, 2012–2016

To investigate transmission of drug-resistant strains of Mycobacterium tuberculosis in Tunisia, we performed whole-genome sequencing on 46 multidrug-resistant strains isolated during 2012–2016. Core-genome multilocus sequence typing grouped 30 strains (65.2%) into 3 clusters, indicating extensive re...

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Detalles Bibliográficos
Autores principales: Bouzouita, Imen, Cabibbe, Andrea Maurizio, Trovato, Alberto, Daroui, Henda, Ghariani, Asma, Midouni, Basma, Essalah, Leila, Mehiri, Emna, Cirillo, Daniela Maria, Saidi, Leila Slim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2019
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390741/
https://www.ncbi.nlm.nih.gov/pubmed/30789128
http://dx.doi.org/10.3201/eid2503.181370
Descripción
Sumario:To investigate transmission of drug-resistant strains of Mycobacterium tuberculosis in Tunisia, we performed whole-genome sequencing on 46 multidrug-resistant strains isolated during 2012–2016. Core-genome multilocus sequence typing grouped 30 strains (65.2%) into 3 clusters, indicating extensive recent transmission and Haarlem clone predominance. Whole-genome sequencing might help public health services undertake appropriate control actions.

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