Whole-Genome Sequencing of Drug-Resistant Mycobacterium tuberculosis Strains, Tunisia, 2012–2016

To investigate transmission of drug-resistant strains of Mycobacterium tuberculosis in Tunisia, we performed whole-genome sequencing on 46 multidrug-resistant strains isolated during 2012–2016. Core-genome multilocus sequence typing grouped 30 strains (65.2%) into 3 clusters, indicating extensive re...

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Autores principales: Bouzouita, Imen, Cabibbe, Andrea Maurizio, Trovato, Alberto, Daroui, Henda, Ghariani, Asma, Midouni, Basma, Essalah, Leila, Mehiri, Emna, Cirillo, Daniela Maria, Saidi, Leila Slim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2019
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390741/
https://www.ncbi.nlm.nih.gov/pubmed/30789128
http://dx.doi.org/10.3201/eid2503.181370
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author Bouzouita, Imen
Cabibbe, Andrea Maurizio
Trovato, Alberto
Daroui, Henda
Ghariani, Asma
Midouni, Basma
Essalah, Leila
Mehiri, Emna
Cirillo, Daniela Maria
Saidi, Leila Slim
author_facet Bouzouita, Imen
Cabibbe, Andrea Maurizio
Trovato, Alberto
Daroui, Henda
Ghariani, Asma
Midouni, Basma
Essalah, Leila
Mehiri, Emna
Cirillo, Daniela Maria
Saidi, Leila Slim
author_sort Bouzouita, Imen
collection PubMed
description To investigate transmission of drug-resistant strains of Mycobacterium tuberculosis in Tunisia, we performed whole-genome sequencing on 46 multidrug-resistant strains isolated during 2012–2016. Core-genome multilocus sequence typing grouped 30 strains (65.2%) into 3 clusters, indicating extensive recent transmission and Haarlem clone predominance. Whole-genome sequencing might help public health services undertake appropriate control actions.
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spelling pubmed-63907412019-03-06 Whole-Genome Sequencing of Drug-Resistant Mycobacterium tuberculosis Strains, Tunisia, 2012–2016 Bouzouita, Imen Cabibbe, Andrea Maurizio Trovato, Alberto Daroui, Henda Ghariani, Asma Midouni, Basma Essalah, Leila Mehiri, Emna Cirillo, Daniela Maria Saidi, Leila Slim Emerg Infect Dis Dispatch To investigate transmission of drug-resistant strains of Mycobacterium tuberculosis in Tunisia, we performed whole-genome sequencing on 46 multidrug-resistant strains isolated during 2012–2016. Core-genome multilocus sequence typing grouped 30 strains (65.2%) into 3 clusters, indicating extensive recent transmission and Haarlem clone predominance. Whole-genome sequencing might help public health services undertake appropriate control actions. Centers for Disease Control and Prevention 2019-03 /pmc/articles/PMC6390741/ /pubmed/30789128 http://dx.doi.org/10.3201/eid2503.181370 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Bouzouita, Imen
Cabibbe, Andrea Maurizio
Trovato, Alberto
Daroui, Henda
Ghariani, Asma
Midouni, Basma
Essalah, Leila
Mehiri, Emna
Cirillo, Daniela Maria
Saidi, Leila Slim
Whole-Genome Sequencing of Drug-Resistant Mycobacterium tuberculosis Strains, Tunisia, 2012–2016
title Whole-Genome Sequencing of Drug-Resistant Mycobacterium tuberculosis Strains, Tunisia, 2012–2016
title_full Whole-Genome Sequencing of Drug-Resistant Mycobacterium tuberculosis Strains, Tunisia, 2012–2016
title_fullStr Whole-Genome Sequencing of Drug-Resistant Mycobacterium tuberculosis Strains, Tunisia, 2012–2016
title_full_unstemmed Whole-Genome Sequencing of Drug-Resistant Mycobacterium tuberculosis Strains, Tunisia, 2012–2016
title_short Whole-Genome Sequencing of Drug-Resistant Mycobacterium tuberculosis Strains, Tunisia, 2012–2016
title_sort whole-genome sequencing of drug-resistant mycobacterium tuberculosis strains, tunisia, 2012–2016
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390741/
https://www.ncbi.nlm.nih.gov/pubmed/30789128
http://dx.doi.org/10.3201/eid2503.181370
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