Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018

Hepatitis E virus (HEV) genotype 4 (HEV-4) is an emerging cause of acute hepatitis in China. Less is known about the clinical characteristics and natural history of HEV-4 than HEV genotype 3 infections in immunocompromised patients. We report transmission of HEV-4 from a deceased organ donor to 5 tr...

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Detalles Bibliográficos
Autores principales: Sridhar, Siddharth, Cheng, Vincent C.C., Wong, Shuk-Ching, Yip, Cyril C.Y., Wu, Shusheng, Lo, Anthony W.I., Leung, Kit-Hang, Mak, Winger W.N., Cai, Jianpiao, Li, Xin, Chan, Jasper F.W., Lau, Susanna K.P., Woo, Patrick C.Y., Lai, Wai-Ming, Kwan, Tze-Hoi, Au, Timmy W.K., Lo, Chung-Mau, Wong, Sally C.Y., Yuen, Kwok-Yung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2019
Materias:
Synopsis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390757/
https://www.ncbi.nlm.nih.gov/pubmed/30789146
http://dx.doi.org/10.3201/eid2503.181563
Descripción
Sumario:Hepatitis E virus (HEV) genotype 4 (HEV-4) is an emerging cause of acute hepatitis in China. Less is known about the clinical characteristics and natural history of HEV-4 than HEV genotype 3 infections in immunocompromised patients. We report transmission of HEV-4 from a deceased organ donor to 5 transplant recipients. The donor had been viremic but HEV IgM and IgG seronegative, and liver function test results were within reference ranges. After a mean of 52 days after transplantation, hepatitis developed in all 5 recipients; in the liver graft recipient, disease was severe and with progressive portal hypertension. Despite reduced immunosuppression, all HEV-4 infections progressed to persistent hepatitis. Four patients received ribavirin and showed evidence of response after 2 months. This study highlights the role of organ donation in HEV transmission, provides additional data on the natural history of HEV-4 infection, and points out differences between genotype 3 and 4 infections in immunocompromised patients.

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