Longitudinal Outbreak of Multidrug-Resistant Tuberculosis in a Hospital Setting, Serbia

A retrospective population-based molecular epidemiologic study of multidrug-resistant Mycobacterium tuberculosis complex strains in Serbia (2008–2014) revealed an outbreak of TUR genotype strains in a psychiatric hospital starting around 1990. Drug unavailability, poor infection control, and schizop...

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Detalles Bibliográficos
Autores principales: Arandjelović, Irena, Merker, Matthias, Richter, Elvira, Kohl, Thomas A., Savić, Branislava, Soldatović, Ivan, Wirth, Thierry, Vuković, Dragana, Niemann, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2019
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390760/
https://www.ncbi.nlm.nih.gov/pubmed/30789133
http://dx.doi.org/10.3201/eid2503.181220
Descripción
Sumario:A retrospective population-based molecular epidemiologic study of multidrug-resistant Mycobacterium tuberculosis complex strains in Serbia (2008–2014) revealed an outbreak of TUR genotype strains in a psychiatric hospital starting around 1990. Drug unavailability, poor infection control, and schizophrenia likely fueled acquisition of additional resistance and bacterial fitness–related mutations over 2 decades.

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