In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR(120)) in Aspergillus fumigatus cyp51A, Denmark

We report a fatal aspergillosis case in which STRAf typing and whole-genome sequencing substantiated in vivo emergence of an azole-resistant Aspergillus fumigatus with a 120-bp tandem repeat in the promoter region of cyp51A. This event, previously restricted to the environment, challenges current un...

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Detalles Bibliográficos
Autores principales: Hare, Rasmus K., Gertsen, Jan B., Astvad, Karen M.T., Degn, Kristine B., Løkke, Anders, Stegger, Marc, Andersen, Paal S., Kristensen, Lise, Arendrup, Maiken C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2019
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390761/
https://www.ncbi.nlm.nih.gov/pubmed/30789127
http://dx.doi.org/10.3201/eid2503.180297
Descripción
Sumario:We report a fatal aspergillosis case in which STRAf typing and whole-genome sequencing substantiated in vivo emergence of an azole-resistant Aspergillus fumigatus with a 120-bp tandem repeat in the promoter region of cyp51A. This event, previously restricted to the environment, challenges current understanding of azole resistance development in A. fumigatus.

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