In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR(120)) in Aspergillus fumigatus cyp51A, Denmark

We report a fatal aspergillosis case in which STRAf typing and whole-genome sequencing substantiated in vivo emergence of an azole-resistant Aspergillus fumigatus with a 120-bp tandem repeat in the promoter region of cyp51A. This event, previously restricted to the environment, challenges current un...

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Autores principales: Hare, Rasmus K., Gertsen, Jan B., Astvad, Karen M.T., Degn, Kristine B., Løkke, Anders, Stegger, Marc, Andersen, Paal S., Kristensen, Lise, Arendrup, Maiken C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2019
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390761/
https://www.ncbi.nlm.nih.gov/pubmed/30789127
http://dx.doi.org/10.3201/eid2503.180297
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author Hare, Rasmus K.
Gertsen, Jan B.
Astvad, Karen M.T.
Degn, Kristine B.
Løkke, Anders
Stegger, Marc
Andersen, Paal S.
Kristensen, Lise
Arendrup, Maiken C.
author_facet Hare, Rasmus K.
Gertsen, Jan B.
Astvad, Karen M.T.
Degn, Kristine B.
Løkke, Anders
Stegger, Marc
Andersen, Paal S.
Kristensen, Lise
Arendrup, Maiken C.
author_sort Hare, Rasmus K.
collection PubMed
description We report a fatal aspergillosis case in which STRAf typing and whole-genome sequencing substantiated in vivo emergence of an azole-resistant Aspergillus fumigatus with a 120-bp tandem repeat in the promoter region of cyp51A. This event, previously restricted to the environment, challenges current understanding of azole resistance development in A. fumigatus.
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spelling pubmed-63907612019-03-06 In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR(120)) in Aspergillus fumigatus cyp51A, Denmark Hare, Rasmus K. Gertsen, Jan B. Astvad, Karen M.T. Degn, Kristine B. Løkke, Anders Stegger, Marc Andersen, Paal S. Kristensen, Lise Arendrup, Maiken C. Emerg Infect Dis Dispatch We report a fatal aspergillosis case in which STRAf typing and whole-genome sequencing substantiated in vivo emergence of an azole-resistant Aspergillus fumigatus with a 120-bp tandem repeat in the promoter region of cyp51A. This event, previously restricted to the environment, challenges current understanding of azole resistance development in A. fumigatus. Centers for Disease Control and Prevention 2019-03 /pmc/articles/PMC6390761/ /pubmed/30789127 http://dx.doi.org/10.3201/eid2503.180297 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Hare, Rasmus K.
Gertsen, Jan B.
Astvad, Karen M.T.
Degn, Kristine B.
Løkke, Anders
Stegger, Marc
Andersen, Paal S.
Kristensen, Lise
Arendrup, Maiken C.
In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR(120)) in Aspergillus fumigatus cyp51A, Denmark
title In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR(120)) in Aspergillus fumigatus cyp51A, Denmark
title_full In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR(120)) in Aspergillus fumigatus cyp51A, Denmark
title_fullStr In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR(120)) in Aspergillus fumigatus cyp51A, Denmark
title_full_unstemmed In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR(120)) in Aspergillus fumigatus cyp51A, Denmark
title_short In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR(120)) in Aspergillus fumigatus cyp51A, Denmark
title_sort in vivo selection of a unique tandem repeat mediated azole resistance mechanism (tr(120)) in aspergillus fumigatus cyp51a, denmark
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390761/
https://www.ncbi.nlm.nih.gov/pubmed/30789127
http://dx.doi.org/10.3201/eid2503.180297
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