Sensing the electrical activity of single ion channels with top-down silicon nanoribbons

Using top-down fabricated silicon nanoribbons, we measure the opening and closing of ion channels alamethicin and gramicidin A. A capacitive model of the system is proposed to demonstrate that the geometric capacitance of the nanoribbon is charged by ion channel currents. The integration of top-down...

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Detalles Bibliográficos
Autores principales: Zhou, Weiwei, Mu, Luye, Li, Jinfeng, Reed, Mark, Burke, Peter J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390970/
https://www.ncbi.nlm.nih.gov/pubmed/30828648
http://dx.doi.org/10.1088/2399-1984/aac737
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author Zhou, Weiwei
Mu, Luye
Li, Jinfeng
Reed, Mark
Burke, Peter J
author_facet Zhou, Weiwei
Mu, Luye
Li, Jinfeng
Reed, Mark
Burke, Peter J
author_sort Zhou, Weiwei
collection PubMed
description Using top-down fabricated silicon nanoribbons, we measure the opening and closing of ion channels alamethicin and gramicidin A. A capacitive model of the system is proposed to demonstrate that the geometric capacitance of the nanoribbon is charged by ion channel currents. The integration of top-down nanoribbons with electrophysiology holds promise for integration of electrically active living systems with artificial electronics.
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spelling pubmed-63909702019-06-01 Sensing the electrical activity of single ion channels with top-down silicon nanoribbons Zhou, Weiwei Mu, Luye Li, Jinfeng Reed, Mark Burke, Peter J Nano Futures Article Using top-down fabricated silicon nanoribbons, we measure the opening and closing of ion channels alamethicin and gramicidin A. A capacitive model of the system is proposed to demonstrate that the geometric capacitance of the nanoribbon is charged by ion channel currents. The integration of top-down nanoribbons with electrophysiology holds promise for integration of electrically active living systems with artificial electronics. 2018-06-12 2018-06 /pmc/articles/PMC6390970/ /pubmed/30828648 http://dx.doi.org/10.1088/2399-1984/aac737 Text en http://creativecommons.org/licenses/by/3.0/ Original content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
spellingShingle Article
Zhou, Weiwei
Mu, Luye
Li, Jinfeng
Reed, Mark
Burke, Peter J
Sensing the electrical activity of single ion channels with top-down silicon nanoribbons
title Sensing the electrical activity of single ion channels with top-down silicon nanoribbons
title_full Sensing the electrical activity of single ion channels with top-down silicon nanoribbons
title_fullStr Sensing the electrical activity of single ion channels with top-down silicon nanoribbons
title_full_unstemmed Sensing the electrical activity of single ion channels with top-down silicon nanoribbons
title_short Sensing the electrical activity of single ion channels with top-down silicon nanoribbons
title_sort sensing the electrical activity of single ion channels with top-down silicon nanoribbons
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390970/
https://www.ncbi.nlm.nih.gov/pubmed/30828648
http://dx.doi.org/10.1088/2399-1984/aac737
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AT reedmark sensingtheelectricalactivityofsingleionchannelswithtopdownsiliconnanoribbons
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