Cargando…

Visualization of basilar artery atherosclerotic plaques by conventional T2-weighted magnetic resonance imaging: A case-control study

OBJECTIVE: In vivo visualization of intracranial atherosclerotic plaque has been performed only with high-resolution magnetic resonance imaging (HRMR). We investigated whether atherosclerotic plaque of the basilar artery (BA) can be identified in conventional magnetic resonance imaging (MRI). METHOD...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Mi Ji, Cho, Soohyun, Cha, Jihoon, Kim, Seonwoo, Kim, Sung Tae, Bang, Oh Young, Chung, Chin-Sang, Lee, Kwang Ho, Kim, Gyeong-Moon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391016/
https://www.ncbi.nlm.nih.gov/pubmed/30807597
http://dx.doi.org/10.1371/journal.pone.0212570
_version_ 1783398242686337024
author Lee, Mi Ji
Cho, Soohyun
Cha, Jihoon
Kim, Seonwoo
Kim, Sung Tae
Bang, Oh Young
Chung, Chin-Sang
Lee, Kwang Ho
Kim, Gyeong-Moon
author_facet Lee, Mi Ji
Cho, Soohyun
Cha, Jihoon
Kim, Seonwoo
Kim, Sung Tae
Bang, Oh Young
Chung, Chin-Sang
Lee, Kwang Ho
Kim, Gyeong-Moon
author_sort Lee, Mi Ji
collection PubMed
description OBJECTIVE: In vivo visualization of intracranial atherosclerotic plaque has been performed only with high-resolution magnetic resonance imaging (HRMR). We investigated whether atherosclerotic plaque of the basilar artery (BA) can be identified in conventional magnetic resonance imaging (MRI). METHODS: Patients with acute ischemic stroke who had BA stenosis (“symptomatic BAA”) were retrospectively recruited using the prospective stroke registry. In the HRMR databank, subjects without BA stenosis were recruited and classified as those with silent plaque (“silent BAA”) and without any plaque (“normal controls”). Outer diameter of the BA and T2 plaque sign (an eccentric or complete obscuration of normal flow-void) within the BA were assessed by two blinded raters using conventional T2 MRI. RESULTS: Seventy-five patients with symptomatic BAA, 40 with asymptomatic BAA, and 36 normal controls were included in the study. Maximal BA diameter was significantly larger in symptomatic BAA patients with <30%, 30–50%, 50–70%, and >70% stenosis (all p<0.01 in each subgroup) and silent BAA subjects (p = 0.018) than controls. T2 plaque signs were present in 46 (61.3%) patients with symptomatic BAA and 6 (14.6%) subjects with asymptomatic BAA, while none in normal controls (p <0.001 and 0.057, respectively). Detection rates were increased with an increase in stenosis degree (25.0% in <30% stenosis, 57.9% in 30–50% stenosis, 38.5% in 50–70% stenosis, 92.3% in 70–99% stenosis, and 100.0% in occlusion). CONCLUSIONS: Our data suggest that BA atherosclerosis can be detected by conventional MRI. When the use of HRMR is limited, conventional MR imaging may give additive information to clinicians.
format Online
Article
Text
id pubmed-6391016
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-63910162019-03-08 Visualization of basilar artery atherosclerotic plaques by conventional T2-weighted magnetic resonance imaging: A case-control study Lee, Mi Ji Cho, Soohyun Cha, Jihoon Kim, Seonwoo Kim, Sung Tae Bang, Oh Young Chung, Chin-Sang Lee, Kwang Ho Kim, Gyeong-Moon PLoS One Research Article OBJECTIVE: In vivo visualization of intracranial atherosclerotic plaque has been performed only with high-resolution magnetic resonance imaging (HRMR). We investigated whether atherosclerotic plaque of the basilar artery (BA) can be identified in conventional magnetic resonance imaging (MRI). METHODS: Patients with acute ischemic stroke who had BA stenosis (“symptomatic BAA”) were retrospectively recruited using the prospective stroke registry. In the HRMR databank, subjects without BA stenosis were recruited and classified as those with silent plaque (“silent BAA”) and without any plaque (“normal controls”). Outer diameter of the BA and T2 plaque sign (an eccentric or complete obscuration of normal flow-void) within the BA were assessed by two blinded raters using conventional T2 MRI. RESULTS: Seventy-five patients with symptomatic BAA, 40 with asymptomatic BAA, and 36 normal controls were included in the study. Maximal BA diameter was significantly larger in symptomatic BAA patients with <30%, 30–50%, 50–70%, and >70% stenosis (all p<0.01 in each subgroup) and silent BAA subjects (p = 0.018) than controls. T2 plaque signs were present in 46 (61.3%) patients with symptomatic BAA and 6 (14.6%) subjects with asymptomatic BAA, while none in normal controls (p <0.001 and 0.057, respectively). Detection rates were increased with an increase in stenosis degree (25.0% in <30% stenosis, 57.9% in 30–50% stenosis, 38.5% in 50–70% stenosis, 92.3% in 70–99% stenosis, and 100.0% in occlusion). CONCLUSIONS: Our data suggest that BA atherosclerosis can be detected by conventional MRI. When the use of HRMR is limited, conventional MR imaging may give additive information to clinicians. Public Library of Science 2019-02-26 /pmc/articles/PMC6391016/ /pubmed/30807597 http://dx.doi.org/10.1371/journal.pone.0212570 Text en © 2019 Lee et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lee, Mi Ji
Cho, Soohyun
Cha, Jihoon
Kim, Seonwoo
Kim, Sung Tae
Bang, Oh Young
Chung, Chin-Sang
Lee, Kwang Ho
Kim, Gyeong-Moon
Visualization of basilar artery atherosclerotic plaques by conventional T2-weighted magnetic resonance imaging: A case-control study
title Visualization of basilar artery atherosclerotic plaques by conventional T2-weighted magnetic resonance imaging: A case-control study
title_full Visualization of basilar artery atherosclerotic plaques by conventional T2-weighted magnetic resonance imaging: A case-control study
title_fullStr Visualization of basilar artery atherosclerotic plaques by conventional T2-weighted magnetic resonance imaging: A case-control study
title_full_unstemmed Visualization of basilar artery atherosclerotic plaques by conventional T2-weighted magnetic resonance imaging: A case-control study
title_short Visualization of basilar artery atherosclerotic plaques by conventional T2-weighted magnetic resonance imaging: A case-control study
title_sort visualization of basilar artery atherosclerotic plaques by conventional t2-weighted magnetic resonance imaging: a case-control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391016/
https://www.ncbi.nlm.nih.gov/pubmed/30807597
http://dx.doi.org/10.1371/journal.pone.0212570
work_keys_str_mv AT leemiji visualizationofbasilararteryatheroscleroticplaquesbyconventionalt2weightedmagneticresonanceimagingacasecontrolstudy
AT chosoohyun visualizationofbasilararteryatheroscleroticplaquesbyconventionalt2weightedmagneticresonanceimagingacasecontrolstudy
AT chajihoon visualizationofbasilararteryatheroscleroticplaquesbyconventionalt2weightedmagneticresonanceimagingacasecontrolstudy
AT kimseonwoo visualizationofbasilararteryatheroscleroticplaquesbyconventionalt2weightedmagneticresonanceimagingacasecontrolstudy
AT kimsungtae visualizationofbasilararteryatheroscleroticplaquesbyconventionalt2weightedmagneticresonanceimagingacasecontrolstudy
AT bangohyoung visualizationofbasilararteryatheroscleroticplaquesbyconventionalt2weightedmagneticresonanceimagingacasecontrolstudy
AT chungchinsang visualizationofbasilararteryatheroscleroticplaquesbyconventionalt2weightedmagneticresonanceimagingacasecontrolstudy
AT leekwangho visualizationofbasilararteryatheroscleroticplaquesbyconventionalt2weightedmagneticresonanceimagingacasecontrolstudy
AT kimgyeongmoon visualizationofbasilararteryatheroscleroticplaquesbyconventionalt2weightedmagneticresonanceimagingacasecontrolstudy