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Visualization of basilar artery atherosclerotic plaques by conventional T2-weighted magnetic resonance imaging: A case-control study
OBJECTIVE: In vivo visualization of intracranial atherosclerotic plaque has been performed only with high-resolution magnetic resonance imaging (HRMR). We investigated whether atherosclerotic plaque of the basilar artery (BA) can be identified in conventional magnetic resonance imaging (MRI). METHOD...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391016/ https://www.ncbi.nlm.nih.gov/pubmed/30807597 http://dx.doi.org/10.1371/journal.pone.0212570 |
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author | Lee, Mi Ji Cho, Soohyun Cha, Jihoon Kim, Seonwoo Kim, Sung Tae Bang, Oh Young Chung, Chin-Sang Lee, Kwang Ho Kim, Gyeong-Moon |
author_facet | Lee, Mi Ji Cho, Soohyun Cha, Jihoon Kim, Seonwoo Kim, Sung Tae Bang, Oh Young Chung, Chin-Sang Lee, Kwang Ho Kim, Gyeong-Moon |
author_sort | Lee, Mi Ji |
collection | PubMed |
description | OBJECTIVE: In vivo visualization of intracranial atherosclerotic plaque has been performed only with high-resolution magnetic resonance imaging (HRMR). We investigated whether atherosclerotic plaque of the basilar artery (BA) can be identified in conventional magnetic resonance imaging (MRI). METHODS: Patients with acute ischemic stroke who had BA stenosis (“symptomatic BAA”) were retrospectively recruited using the prospective stroke registry. In the HRMR databank, subjects without BA stenosis were recruited and classified as those with silent plaque (“silent BAA”) and without any plaque (“normal controls”). Outer diameter of the BA and T2 plaque sign (an eccentric or complete obscuration of normal flow-void) within the BA were assessed by two blinded raters using conventional T2 MRI. RESULTS: Seventy-five patients with symptomatic BAA, 40 with asymptomatic BAA, and 36 normal controls were included in the study. Maximal BA diameter was significantly larger in symptomatic BAA patients with <30%, 30–50%, 50–70%, and >70% stenosis (all p<0.01 in each subgroup) and silent BAA subjects (p = 0.018) than controls. T2 plaque signs were present in 46 (61.3%) patients with symptomatic BAA and 6 (14.6%) subjects with asymptomatic BAA, while none in normal controls (p <0.001 and 0.057, respectively). Detection rates were increased with an increase in stenosis degree (25.0% in <30% stenosis, 57.9% in 30–50% stenosis, 38.5% in 50–70% stenosis, 92.3% in 70–99% stenosis, and 100.0% in occlusion). CONCLUSIONS: Our data suggest that BA atherosclerosis can be detected by conventional MRI. When the use of HRMR is limited, conventional MR imaging may give additive information to clinicians. |
format | Online Article Text |
id | pubmed-6391016 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-63910162019-03-08 Visualization of basilar artery atherosclerotic plaques by conventional T2-weighted magnetic resonance imaging: A case-control study Lee, Mi Ji Cho, Soohyun Cha, Jihoon Kim, Seonwoo Kim, Sung Tae Bang, Oh Young Chung, Chin-Sang Lee, Kwang Ho Kim, Gyeong-Moon PLoS One Research Article OBJECTIVE: In vivo visualization of intracranial atherosclerotic plaque has been performed only with high-resolution magnetic resonance imaging (HRMR). We investigated whether atherosclerotic plaque of the basilar artery (BA) can be identified in conventional magnetic resonance imaging (MRI). METHODS: Patients with acute ischemic stroke who had BA stenosis (“symptomatic BAA”) were retrospectively recruited using the prospective stroke registry. In the HRMR databank, subjects without BA stenosis were recruited and classified as those with silent plaque (“silent BAA”) and without any plaque (“normal controls”). Outer diameter of the BA and T2 plaque sign (an eccentric or complete obscuration of normal flow-void) within the BA were assessed by two blinded raters using conventional T2 MRI. RESULTS: Seventy-five patients with symptomatic BAA, 40 with asymptomatic BAA, and 36 normal controls were included in the study. Maximal BA diameter was significantly larger in symptomatic BAA patients with <30%, 30–50%, 50–70%, and >70% stenosis (all p<0.01 in each subgroup) and silent BAA subjects (p = 0.018) than controls. T2 plaque signs were present in 46 (61.3%) patients with symptomatic BAA and 6 (14.6%) subjects with asymptomatic BAA, while none in normal controls (p <0.001 and 0.057, respectively). Detection rates were increased with an increase in stenosis degree (25.0% in <30% stenosis, 57.9% in 30–50% stenosis, 38.5% in 50–70% stenosis, 92.3% in 70–99% stenosis, and 100.0% in occlusion). CONCLUSIONS: Our data suggest that BA atherosclerosis can be detected by conventional MRI. When the use of HRMR is limited, conventional MR imaging may give additive information to clinicians. Public Library of Science 2019-02-26 /pmc/articles/PMC6391016/ /pubmed/30807597 http://dx.doi.org/10.1371/journal.pone.0212570 Text en © 2019 Lee et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Lee, Mi Ji Cho, Soohyun Cha, Jihoon Kim, Seonwoo Kim, Sung Tae Bang, Oh Young Chung, Chin-Sang Lee, Kwang Ho Kim, Gyeong-Moon Visualization of basilar artery atherosclerotic plaques by conventional T2-weighted magnetic resonance imaging: A case-control study |
title | Visualization of basilar artery atherosclerotic plaques by conventional T2-weighted magnetic resonance imaging: A case-control study |
title_full | Visualization of basilar artery atherosclerotic plaques by conventional T2-weighted magnetic resonance imaging: A case-control study |
title_fullStr | Visualization of basilar artery atherosclerotic plaques by conventional T2-weighted magnetic resonance imaging: A case-control study |
title_full_unstemmed | Visualization of basilar artery atherosclerotic plaques by conventional T2-weighted magnetic resonance imaging: A case-control study |
title_short | Visualization of basilar artery atherosclerotic plaques by conventional T2-weighted magnetic resonance imaging: A case-control study |
title_sort | visualization of basilar artery atherosclerotic plaques by conventional t2-weighted magnetic resonance imaging: a case-control study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391016/ https://www.ncbi.nlm.nih.gov/pubmed/30807597 http://dx.doi.org/10.1371/journal.pone.0212570 |
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