The molecular basis for an allosteric inhibition of K(+)-flux gating in K(2P) channels

Two-pore-domain potassium (K(2P)) channels are key regulators of many physiological and pathophysiological processes and thus emerged as promising drug targets. As for other potassium channels, there is a lack of selective blockers, since drugs preferentially bind to a conserved binding site located...

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Detalles Bibliográficos
Autores principales: Rinné, Susanne, Kiper, Aytug K, Vowinkel, Kirsty S, Ramírez, David, Schewe, Marcus, Bedoya, Mauricio, Aser, Diana, Gensler, Isabella, Netter, Michael F, Stansfeld, Phillip J, Baukrowitz, Thomas, Gonzalez, Wendy, Decher, Niels
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391080/
https://www.ncbi.nlm.nih.gov/pubmed/30803485
http://dx.doi.org/10.7554/eLife.39476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391080/
https://www.ncbi.nlm.nih.gov/pubmed/30803485
http://dx.doi.org/10.7554/eLife.39476

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