Cargando…
The molecular basis for an allosteric inhibition of K(+)-flux gating in K(2P) channels
Two-pore-domain potassium (K(2P)) channels are key regulators of many physiological and pathophysiological processes and thus emerged as promising drug targets. As for other potassium channels, there is a lack of selective blockers, since drugs preferentially bind to a conserved binding site located...
| Autores principales: | , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391080/ https://www.ncbi.nlm.nih.gov/pubmed/30803485 http://dx.doi.org/10.7554/eLife.39476 |