Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice

Atypical hemolytic uremic syndrome (aHUS) is frequently associated in humans with loss-of-function mutations in complement-regulating proteins or gain-of-function mutations in complement-activating proteins. Thus, aHUS provides an archetypal complement-mediated disease with which to model new therap...

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Detalles Bibliográficos
Autores principales: Smith-Jackson, Kate, Yang, Yi, Denton, Harriet, Pappworth, Isabel Y., Cooke, Katie, Barlow, Paul N., Atkinson, John P., Liszewski, M. Kathryn, Pickering, Matthew C., Kavanagh, David, Cook, H. Terence, Marchbank, Kevin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391106/
https://www.ncbi.nlm.nih.gov/pubmed/30714990
http://dx.doi.org/10.1172/JCI99296

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