Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells

Chronic stress triggers activation of the sympathetic nervous system and drives malignancy. Using an immunodeficient murine system, we showed that chronic stress–induced epinephrine promoted breast cancer stem-like properties via lactate dehydrogenase A–dependent (LDHA-dependent) metabolic rewiring....

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Detalles Bibliográficos
Autores principales: Cui, Bai, Luo, Yuanyuan, Tian, Pengfei, Peng, Fei, Lu, Jinxin, Yang, Yongliang, Su, Qitong, Liu, Bing, Yu, Jiachuan, Luo, Xi, Yin, Liu, Cheng, Wei, An, Fan, He, Bin, Liang, Dapeng, Wu, Sijin, Chu, Peng, Song, Luyao, Liu, Xinyu, Luo, Huandong, Xu, Jie, Pan, Yujia, Wang, Yang, Li, Dangsheng, Huang, Peng, Yang, Qingkai, Zhang, Lingqiang, Zhou, Binhua P., Liu, Suling, Xu, Guowang, Lam, Eric W.-F., Kelley, Keith W., Liu, Quentin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391112/
https://www.ncbi.nlm.nih.gov/pubmed/30688660
http://dx.doi.org/10.1172/JCI121685

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