Comparative Efficacies of Linezolid vs. Tedizolid in an Experimental Murine Model of Vancomycin-Resistant Enterococcal (VRE) Bacteremia

Tedizolid (TZD) is an oxazolidinone derivative which demonstrates bacteriostatic activity through inhibition of protein synthesis. We compared the efficacies of TZD and an earlier-generation oxazolidinone, linezolid (LZD), in an experimental murine model of bacteremia caused by two VRE strains (one...

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Autores principales: Abdelhady, Wessam, Mishra, Nagendra N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391330/
https://www.ncbi.nlm.nih.gov/pubmed/30842947
http://dx.doi.org/10.3389/fmed.2019.00031
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author Abdelhady, Wessam
Mishra, Nagendra N.
author_facet Abdelhady, Wessam
Mishra, Nagendra N.
author_sort Abdelhady, Wessam
collection PubMed
description Tedizolid (TZD) is an oxazolidinone derivative which demonstrates bacteriostatic activity through inhibition of protein synthesis. We compared the efficacies of TZD and an earlier-generation oxazolidinone, linezolid (LZD), in an experimental murine model of bacteremia caused by two VRE strains (one each E. faecium and E. faecalis). LZD exhibited significantly better efficacy in terms of reduced VRE blood and target tissue densities than TZD in this model.
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spelling pubmed-63913302019-03-06 Comparative Efficacies of Linezolid vs. Tedizolid in an Experimental Murine Model of Vancomycin-Resistant Enterococcal (VRE) Bacteremia Abdelhady, Wessam Mishra, Nagendra N. Front Med (Lausanne) Medicine Tedizolid (TZD) is an oxazolidinone derivative which demonstrates bacteriostatic activity through inhibition of protein synthesis. We compared the efficacies of TZD and an earlier-generation oxazolidinone, linezolid (LZD), in an experimental murine model of bacteremia caused by two VRE strains (one each E. faecium and E. faecalis). LZD exhibited significantly better efficacy in terms of reduced VRE blood and target tissue densities than TZD in this model. Frontiers Media S.A. 2019-02-20 /pmc/articles/PMC6391330/ /pubmed/30842947 http://dx.doi.org/10.3389/fmed.2019.00031 Text en Copyright © 2019 Abdelhady and Mishra. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Abdelhady, Wessam
Mishra, Nagendra N.
Comparative Efficacies of Linezolid vs. Tedizolid in an Experimental Murine Model of Vancomycin-Resistant Enterococcal (VRE) Bacteremia
title Comparative Efficacies of Linezolid vs. Tedizolid in an Experimental Murine Model of Vancomycin-Resistant Enterococcal (VRE) Bacteremia
title_full Comparative Efficacies of Linezolid vs. Tedizolid in an Experimental Murine Model of Vancomycin-Resistant Enterococcal (VRE) Bacteremia
title_fullStr Comparative Efficacies of Linezolid vs. Tedizolid in an Experimental Murine Model of Vancomycin-Resistant Enterococcal (VRE) Bacteremia
title_full_unstemmed Comparative Efficacies of Linezolid vs. Tedizolid in an Experimental Murine Model of Vancomycin-Resistant Enterococcal (VRE) Bacteremia
title_short Comparative Efficacies of Linezolid vs. Tedizolid in an Experimental Murine Model of Vancomycin-Resistant Enterococcal (VRE) Bacteremia
title_sort comparative efficacies of linezolid vs. tedizolid in an experimental murine model of vancomycin-resistant enterococcal (vre) bacteremia
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391330/
https://www.ncbi.nlm.nih.gov/pubmed/30842947
http://dx.doi.org/10.3389/fmed.2019.00031
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