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Reprogrammed CD4(+) T Cells That Express FoxP3(+) Control Inhibitory Antibody Formation in Hemophilia A Mice

Coagulation Factor VIII (FVIII) replacement therapy in hemophilia A patients is complicated by the development of inhibitory antibodies, which often render the treatment ineffective. Previous studies demonstrated a strong correlation between induction of regulatory T cells (Treg) and tolerance to th...

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Detalles Bibliográficos
Autores principales: Herzog, Roland W., Kuteyeva, Veronica, Saboungi, Rania, Terhorst, Cox, Biswas, Moanaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391332/
https://www.ncbi.nlm.nih.gov/pubmed/30842776
http://dx.doi.org/10.3389/fimmu.2019.00274