Metformin and glucose starvation decrease the migratory ability of hepatocellular carcinoma cells: targeting AMPK activation to control migration

Hepatocellular carcinoma (HCC) is a highly metastatic cancer with very poor prognosis. AMP activated kinase (AMPK) constitutes a candidate to inhibit HCC progression. First, AMPK is downregulated in HCC. Second, glucose starvation induces apoptosis in HCC cells via AMPK. Correspondingly, metformin a...

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Detalles Bibliográficos
Autores principales: Ferretti, Anabela C., Hidalgo, Florencia, Tonucci, Facundo M., Almada, Evangelina, Pariani, Alejandro, Larocca, María C., Favre, Cristián
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391381/
https://www.ncbi.nlm.nih.gov/pubmed/30809021
http://dx.doi.org/10.1038/s41598-019-39556-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391381/
https://www.ncbi.nlm.nih.gov/pubmed/30809021
http://dx.doi.org/10.1038/s41598-019-39556-w

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