Metal- and solvent-free synthesis of amides using substitute formamides as an amino source under mild conditions

This study described an efficient and practical approach for amide synthesis. The reaction was conducted under metal- and solvent-free conditions at a mild temperature (40 °C) in air, and readily available formamides were used as an amino source. This reaction can be easily upgraded to the gram leve...

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Detalles Bibliográficos
Autores principales: Zhang, Feng, Li, Lesong, Zhang, Jingyu, Gong, Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391388/
https://www.ncbi.nlm.nih.gov/pubmed/30808919
http://dx.doi.org/10.1038/s41598-019-39240-z
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author Zhang, Feng
Li, Lesong
Zhang, Jingyu
Gong, Hang
author_facet Zhang, Feng
Li, Lesong
Zhang, Jingyu
Gong, Hang
author_sort Zhang, Feng
collection PubMed
description This study described an efficient and practical approach for amide synthesis. The reaction was conducted under metal- and solvent-free conditions at a mild temperature (40 °C) in air, and readily available formamides were used as an amino source. This reaction can be easily upgraded to the gram level with an excellent yield.
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spelling pubmed-63913882019-02-28 Metal- and solvent-free synthesis of amides using substitute formamides as an amino source under mild conditions Zhang, Feng Li, Lesong Zhang, Jingyu Gong, Hang Sci Rep Article This study described an efficient and practical approach for amide synthesis. The reaction was conducted under metal- and solvent-free conditions at a mild temperature (40 °C) in air, and readily available formamides were used as an amino source. This reaction can be easily upgraded to the gram level with an excellent yield. Nature Publishing Group UK 2019-02-26 /pmc/articles/PMC6391388/ /pubmed/30808919 http://dx.doi.org/10.1038/s41598-019-39240-z Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zhang, Feng
Li, Lesong
Zhang, Jingyu
Gong, Hang
Metal- and solvent-free synthesis of amides using substitute formamides as an amino source under mild conditions
title Metal- and solvent-free synthesis of amides using substitute formamides as an amino source under mild conditions
title_full Metal- and solvent-free synthesis of amides using substitute formamides as an amino source under mild conditions
title_fullStr Metal- and solvent-free synthesis of amides using substitute formamides as an amino source under mild conditions
title_full_unstemmed Metal- and solvent-free synthesis of amides using substitute formamides as an amino source under mild conditions
title_short Metal- and solvent-free synthesis of amides using substitute formamides as an amino source under mild conditions
title_sort metal- and solvent-free synthesis of amides using substitute formamides as an amino source under mild conditions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391388/
https://www.ncbi.nlm.nih.gov/pubmed/30808919
http://dx.doi.org/10.1038/s41598-019-39240-z
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AT zhangjingyu metalandsolventfreesynthesisofamidesusingsubstituteformamidesasanaminosourceundermildconditions
AT gonghang metalandsolventfreesynthesisofamidesusingsubstituteformamidesasanaminosourceundermildconditions

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