G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma

Mutational inactivation of ATRX (α-thalassemia mental retardation X-linked) represents a defining molecular alteration in large subsets of malignant glioma. Yet the pathogenic consequences of ATRX deficiency remain unclear, as do tractable mechanisms for its therapeutic targeting. Here we report tha...

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Detalles Bibliográficos
Autores principales: Wang, Yuxiang, Yang, Jie, Wild, Aaron T., Wu, Wei H., Shah, Rachna, Danussi, Carla, Riggins, Gregory J., Kannan, Kasthuri, Sulman, Erik P., Chan, Timothy A., Huse, Jason T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391399/
https://www.ncbi.nlm.nih.gov/pubmed/30808951
http://dx.doi.org/10.1038/s41467-019-08905-8

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