Hypermethylation of Frizzled1 is associated with Wnt/β-catenin signaling inactivation in mesenchymal stem cells of patients with steroid-associated osteonecrosis

The Wnt/β-catenin signaling pathway is associated with the pathogenesis of steroid-induced osteonecrosis. Our investigation studied whether aberrant CpG island hypermethylation of the FZD1 gene was present in patients with osteonecrosis of the femoral head (ONFH), which results in Wnt/β-catenin sign...

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Detalles Bibliográficos
Autores principales: Wu, Fei, Jiao, Jing, Liu, Feng, Yang, Yue, Zhang, Shanfeng, Fang, Zhenhua, Dai, Zhipeng, Sun, Zhibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391470/
https://www.ncbi.nlm.nih.gov/pubmed/30808872
http://dx.doi.org/10.1038/s12276-019-0220-8

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