Immunotherapy for advanced lung cancer combined with surgery for mediastinal myxofibrosarcoma: a case report

BACKGROUND: It is unclear whether simultaneous primary neoplasm resection and immunotherapy for advanced lung cancer is safe. We report a case of an elderly man with advanced lung cancer and myxofibrosarcoma. CASE PRESENTATION: The advanced lung cancer was treated with pembrolizumab, and partial res...

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Detalles Bibliográficos
Autores principales: Fukui, Tetsuya, Wakatsuki, Yusuke, Matsukura, Tadashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391501/
https://www.ncbi.nlm.nih.gov/pubmed/30806844
http://dx.doi.org/10.1186/s40792-019-0596-7
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author Fukui, Tetsuya
Wakatsuki, Yusuke
Matsukura, Tadashi
author_facet Fukui, Tetsuya
Wakatsuki, Yusuke
Matsukura, Tadashi
author_sort Fukui, Tetsuya
collection PubMed
description BACKGROUND: It is unclear whether simultaneous primary neoplasm resection and immunotherapy for advanced lung cancer is safe. We report a case of an elderly man with advanced lung cancer and myxofibrosarcoma. CASE PRESENTATION: The advanced lung cancer was treated with pembrolizumab, and partial response was achieved in 3 months. However, the mediastinal cyst enlarged rapidly. We resected the mediastinal tumor and diagnosed it as myxofibrosarcoma. The postoperative course was uneventful. Immunotherapy was resumed after the operation without any adverse effects. No recurrence of mediastinal sarcoma or progression of lung cancer was found until the patient died in an accident 8 months after surgery. CONCLUSION: Surgery for mediastinal sarcoma could be performed safely in combination with immunotherapy for advanced lung cancer.
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spelling pubmed-63915012019-03-14 Immunotherapy for advanced lung cancer combined with surgery for mediastinal myxofibrosarcoma: a case report Fukui, Tetsuya Wakatsuki, Yusuke Matsukura, Tadashi Surg Case Rep Case Report BACKGROUND: It is unclear whether simultaneous primary neoplasm resection and immunotherapy for advanced lung cancer is safe. We report a case of an elderly man with advanced lung cancer and myxofibrosarcoma. CASE PRESENTATION: The advanced lung cancer was treated with pembrolizumab, and partial response was achieved in 3 months. However, the mediastinal cyst enlarged rapidly. We resected the mediastinal tumor and diagnosed it as myxofibrosarcoma. The postoperative course was uneventful. Immunotherapy was resumed after the operation without any adverse effects. No recurrence of mediastinal sarcoma or progression of lung cancer was found until the patient died in an accident 8 months after surgery. CONCLUSION: Surgery for mediastinal sarcoma could be performed safely in combination with immunotherapy for advanced lung cancer. Springer Berlin Heidelberg 2019-02-26 /pmc/articles/PMC6391501/ /pubmed/30806844 http://dx.doi.org/10.1186/s40792-019-0596-7 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Case Report
Fukui, Tetsuya
Wakatsuki, Yusuke
Matsukura, Tadashi
Immunotherapy for advanced lung cancer combined with surgery for mediastinal myxofibrosarcoma: a case report
title Immunotherapy for advanced lung cancer combined with surgery for mediastinal myxofibrosarcoma: a case report
title_full Immunotherapy for advanced lung cancer combined with surgery for mediastinal myxofibrosarcoma: a case report
title_fullStr Immunotherapy for advanced lung cancer combined with surgery for mediastinal myxofibrosarcoma: a case report
title_full_unstemmed Immunotherapy for advanced lung cancer combined with surgery for mediastinal myxofibrosarcoma: a case report
title_short Immunotherapy for advanced lung cancer combined with surgery for mediastinal myxofibrosarcoma: a case report
title_sort immunotherapy for advanced lung cancer combined with surgery for mediastinal myxofibrosarcoma: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391501/
https://www.ncbi.nlm.nih.gov/pubmed/30806844
http://dx.doi.org/10.1186/s40792-019-0596-7
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