Mutations in the dimer interfaces of the dengue virus capsid protein affect structural stability and impair RNA-capsid interaction

The dengue virus 2 capsid protein (DENV2C) plays a primary structural role in the protection of the viral genome and is crucial for nucleocapsid assembly. In this study, we generated single mutants of DENV2C at L50 and L54 residues of the α2 helix, which was shown to interfere with the integration o...

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Detalles Bibliográficos
Autores principales: Figueira-Mansur, Janaina, Aguilera, Estefania A., Stoque, Rafael M., Ventura, Gustavo T., Mohana-Borges, Ronaldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391532/
https://www.ncbi.nlm.nih.gov/pubmed/30808916
http://dx.doi.org/10.1038/s41598-019-39185-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391532/
https://www.ncbi.nlm.nih.gov/pubmed/30808916
http://dx.doi.org/10.1038/s41598-019-39185-3

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