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Mutations in the dimer interfaces of the dengue virus capsid protein affect structural stability and impair RNA-capsid interaction
The dengue virus 2 capsid protein (DENV2C) plays a primary structural role in the protection of the viral genome and is crucial for nucleocapsid assembly. In this study, we generated single mutants of DENV2C at L50 and L54 residues of the α2 helix, which was shown to interfere with the integration o...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391532/ https://www.ncbi.nlm.nih.gov/pubmed/30808916 http://dx.doi.org/10.1038/s41598-019-39185-3 |