Randomized trial of intermittent intraputamenal glial cell line-derived neurotrophic factor in Parkinson’s disease

We investigated the effects of glial cell line-derived neurotrophic factor (GDNF) in Parkinson’s disease, using intermittent intraputamenal convection-enhanced delivery via a skull-mounted transcutaneous port as a novel administration paradigm to potentially afford putamen-wide therapeutic delivery....

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Detalles Bibliográficos
Autores principales: Whone, Alan, Luz, Matthias, Boca, Mihaela, Woolley, Max, Mooney, Lucy, Dharia, Sonali, Broadfoot, Jack, Cronin, David, Schroers, Christian, Barua, Neil U, Longpre, Lara, Barclay, C Lynn, Boiko, Chris, Johnson, Greg A, Fibiger, H Christian, Harrison, Rob, Lewis, Owen, Pritchard, Gemma, Howell, Mike, Irving, Charlie, Johnson, David, Kinch, Suk, Marshall, Christopher, Lawrence, Andrew D, Blinder, Stephan, Sossi, Vesna, Stoessl, A Jon, Skinner, Paul, Mohr, Erich, Gill, Steven S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Clinical Trial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391602/
https://www.ncbi.nlm.nih.gov/pubmed/30808022
http://dx.doi.org/10.1093/brain/awz023

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