Use of amantadine as substrate for SSAT-1 activity as a reliable clinical diagnostic assay for breast and lung cancer

AIM: Spermidine/spermine N(1)-acetyltransferase (SSAT-1) plays a critical role in cell growth, proliferation and death, and is known to be activated in human cancer cells. Amantadine, a US FDA-approved antiviral drug, is a substrate for SSAT-1 and can be used to indirectly measure SSAT-1 activity be...

Descripción completa

Detalles Bibliográficos
Autores principales: Maksymiuk, Andrew W, Tappia, Paramjit S, Sitar, Daniel S, Akhtar, Parveen S, Khatun, Nazrina, Parveen, Rahnuma, Ahmed, Rashiduzzaman, Ahmed, Rashid Bux, Cheng, Brian, Huang, Gina, Bach, Horacio, Hiebert, Brett, Ramjiawan, Bram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391627/
https://www.ncbi.nlm.nih.gov/pubmed/30820345
http://dx.doi.org/10.4155/fsoa-2018-0106
Descripción
Sumario:AIM: Spermidine/spermine N(1)-acetyltransferase (SSAT-1) plays a critical role in cell growth, proliferation and death, and is known to be activated in human cancer cells. Amantadine, a US FDA-approved antiviral drug, is a substrate for SSAT-1 and can be used to indirectly measure SSAT-1 activity because of its conversion to acetylamantadine (AA). This study was undertaken to further validate SSAT-1 activity in breast and lung cancer patients. RESULTS: An increase in the urinary concentration of AA in lung and breast cancer patients was observed. The 0–2 h collection time point was determined to be optimal in revealing significant differences in urinary AA concentration between healthy controls and cancer patients. CONCLUSION: The high urine concentration of AA could be used as a simple and useful test for the detection of breast and lung cancer.

Ejemplares similares