Use of amantadine as substrate for SSAT-1 activity as a reliable clinical diagnostic assay for breast and lung cancer

AIM: Spermidine/spermine N(1)-acetyltransferase (SSAT-1) plays a critical role in cell growth, proliferation and death, and is known to be activated in human cancer cells. Amantadine, a US FDA-approved antiviral drug, is a substrate for SSAT-1 and can be used to indirectly measure SSAT-1 activity be...

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Detalles Bibliográficos
Autores principales: Maksymiuk, Andrew W, Tappia, Paramjit S, Sitar, Daniel S, Akhtar, Parveen S, Khatun, Nazrina, Parveen, Rahnuma, Ahmed, Rashiduzzaman, Ahmed, Rashid Bux, Cheng, Brian, Huang, Gina, Bach, Horacio, Hiebert, Brett, Ramjiawan, Bram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391627/
https://www.ncbi.nlm.nih.gov/pubmed/30820345
http://dx.doi.org/10.4155/fsoa-2018-0106

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