Main constraints for RNAi induced by expressed long dsRNA in mouse cells

RNAi is the sequence-specific mRNA degradation guided by siRNAs produced from long dsRNA by RNase Dicer. Proteins executing RNAi are present in mammalian cells but rather sustain the microRNA pathway. Aiming for a systematic analysis of mammalian RNAi, we report here that the main bottleneck for RNA...

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Detalles Bibliográficos
Autores principales: Demeter, Tomas, Vaskovicova, Michaela, Malik, Radek, Horvat, Filip, Pasulka, Josef, Svobodova, Eliska, Flemr, Matyas, Svoboda, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391682/
https://www.ncbi.nlm.nih.gov/pubmed/30808654
http://dx.doi.org/10.26508/lsa.201800289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391682/
https://www.ncbi.nlm.nih.gov/pubmed/30808654
http://dx.doi.org/10.26508/lsa.201800289

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