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SH3BP4 Regulates Intestinal Stem Cells and Tumorigenesis by Modulating β-Catenin Nuclear Localization

Wnt signals at the base of mammalian crypts play a pivotal role in intestinal stem cell (ISC) homeostasis, whereas aberrant Wnt activation causes colon cancer. Precise control of Wnt signal strength is governed by a number of negative inhibitory mechanisms acting at distinct levels of the cascade. H...

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Detalles Bibliográficos
Autores principales:	Antas, Pedro, Novellasdemunt, Laura, Kucharska, Anna, Massie, Isobel, Carvalho, Joana, Oukrif, Dahmane, Nye, Emma, Novelli, Marco, Li, Vivian S.W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391711/ https://www.ncbi.nlm.nih.gov/pubmed/30811977 http://dx.doi.org/10.1016/j.celrep.2019.01.110

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