Pulmonary arterial remodelling by deficiency of peroxisome proliferator-activated receptor-γ in murine vascular smooth muscle cells occurs independently of obesity-related pulmonary hypertension

BACKGROUND: Obesity is associated with cardiovascular complications, including pulmonary hypertension (PH). Reports suggest that peroxisome proliferator-activated receptor-γ (PPARγ) has direct action in preventing vascular remodelling in PH. Here we dissected the specific role of high-fat-diet (HFD)...

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Detalles Bibliográficos
Autores principales: Caglayan, Evren, Trappiel, Manuela, Behringer, Arnica, Berghausen, Eva Maria, Odenthal, Margarete, Wellnhofer, Ernst, Kappert, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391752/
https://www.ncbi.nlm.nih.gov/pubmed/30813929
http://dx.doi.org/10.1186/s12931-019-1003-4

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