LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice

Mutations in leucine-rich repeat kinase 2 (LRRK2) are one of the most common causes of familial Parkinson’s disease (PD). The most common mutations in the LRRK2 gene induce elevated kinase activity of the LRRK2 protein. Recent studies have also suggested that LRRK2 kinase activity may be elevated in...

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Detalles Bibliográficos
Autores principales: Henderson, Michael X., Sengupta, Medha, McGeary, Ian, Zhang, Bin, Olufemi, Modupe F., Brown, Hannah, Trojanowski, John Q., Lee, Virginia M. Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391792/
https://www.ncbi.nlm.nih.gov/pubmed/30808409
http://dx.doi.org/10.1186/s40478-019-0679-5

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