Cargando…

Cognitive function in Prefrail and frail community-dwelling older adults in China

BACKGROUND: Physical frailty, characterized by reduced physiologic complexity and ability to cope with stressors, is closely associated with cognitive impairment, which increases the risk of poor clinical outcomes. To better capture the association between frailty and cognitive impairment, a new con...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Lina, Zhang, Li, Sun, Fei, Li, Yun, Tang, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391822/
https://www.ncbi.nlm.nih.gov/pubmed/30813907
http://dx.doi.org/10.1186/s12877-019-1056-8
_version_ 1783398373067325440
author Ma, Lina
Zhang, Li
Sun, Fei
Li, Yun
Tang, Zhe
author_facet Ma, Lina
Zhang, Li
Sun, Fei
Li, Yun
Tang, Zhe
author_sort Ma, Lina
collection PubMed
description BACKGROUND: Physical frailty, characterized by reduced physiologic complexity and ability to cope with stressors, is closely associated with cognitive impairment, which increases the risk of poor clinical outcomes. To better capture the association between frailty and cognitive impairment, a new construct, cognitive frailty, has been proposed. Cognitive frailty is a clinical condition characterized by the simultaneous presence of physical frailty and cognitive impairment. There is little evidence on the relationship between physical frailty and cognition, as well as cognitive frailty, in Chinese older adults. We aimed to elucidate whether physical frailty is associated with cognitive impairment in an older Chinese population. METHODS: Data were obtained from the China Comprehensive Geriatric Assessment Study. The sample comprised 3202 community-dwelling adults, aged 60 years and older, from seven Chinese cities. Physical frailty was assessed using a modified, four-item version of the Fried criteria, according to frailty phenotype. Cognitive function was assessed using the Mini-Mental State Examination (MMSE). RESULTS: The prevalence of physical frailty, prefrailty, cognitive impairment, and cognitive frailty was 9.9, 33.9, 7.5, and 2.3%, respectively (weighted: 8.8, 33.8, 6.5, and 2.0%). The prevalence of the combination of prefrail/frail and cognitive impairment was 5.1% (weighted 4.5%). Frail participants performed worse on global cognition and all cognitive domains than robust and prefrail participants. The MMSE total score was positively correlated with walking speed and negatively correlated with age and frailty. A multivariate logistic regression revealed that after adjusting for age, gender, education level, living area, and chronic diseases, frailty, exhaustion, slowness, and inactivity were significantly associated with poor global cognition. CONCLUSIONS: The standard prevalence of physical frailty, prefrailty, cognitive impairment, and cognitive frailty in community-dwelling older adults in China was 8.8, 33.8, 6.5, and 2.0%, respectively. Frailty, exhaustion, slowness, and inactivity were significantly associated with poor global cognition.
format Online
Article
Text
id pubmed-6391822
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-63918222019-03-11 Cognitive function in Prefrail and frail community-dwelling older adults in China Ma, Lina Zhang, Li Sun, Fei Li, Yun Tang, Zhe BMC Geriatr Research Article BACKGROUND: Physical frailty, characterized by reduced physiologic complexity and ability to cope with stressors, is closely associated with cognitive impairment, which increases the risk of poor clinical outcomes. To better capture the association between frailty and cognitive impairment, a new construct, cognitive frailty, has been proposed. Cognitive frailty is a clinical condition characterized by the simultaneous presence of physical frailty and cognitive impairment. There is little evidence on the relationship between physical frailty and cognition, as well as cognitive frailty, in Chinese older adults. We aimed to elucidate whether physical frailty is associated with cognitive impairment in an older Chinese population. METHODS: Data were obtained from the China Comprehensive Geriatric Assessment Study. The sample comprised 3202 community-dwelling adults, aged 60 years and older, from seven Chinese cities. Physical frailty was assessed using a modified, four-item version of the Fried criteria, according to frailty phenotype. Cognitive function was assessed using the Mini-Mental State Examination (MMSE). RESULTS: The prevalence of physical frailty, prefrailty, cognitive impairment, and cognitive frailty was 9.9, 33.9, 7.5, and 2.3%, respectively (weighted: 8.8, 33.8, 6.5, and 2.0%). The prevalence of the combination of prefrail/frail and cognitive impairment was 5.1% (weighted 4.5%). Frail participants performed worse on global cognition and all cognitive domains than robust and prefrail participants. The MMSE total score was positively correlated with walking speed and negatively correlated with age and frailty. A multivariate logistic regression revealed that after adjusting for age, gender, education level, living area, and chronic diseases, frailty, exhaustion, slowness, and inactivity were significantly associated with poor global cognition. CONCLUSIONS: The standard prevalence of physical frailty, prefrailty, cognitive impairment, and cognitive frailty in community-dwelling older adults in China was 8.8, 33.8, 6.5, and 2.0%, respectively. Frailty, exhaustion, slowness, and inactivity were significantly associated with poor global cognition. BioMed Central 2019-02-27 /pmc/articles/PMC6391822/ /pubmed/30813907 http://dx.doi.org/10.1186/s12877-019-1056-8 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Ma, Lina
Zhang, Li
Sun, Fei
Li, Yun
Tang, Zhe
Cognitive function in Prefrail and frail community-dwelling older adults in China
title Cognitive function in Prefrail and frail community-dwelling older adults in China
title_full Cognitive function in Prefrail and frail community-dwelling older adults in China
title_fullStr Cognitive function in Prefrail and frail community-dwelling older adults in China
title_full_unstemmed Cognitive function in Prefrail and frail community-dwelling older adults in China
title_short Cognitive function in Prefrail and frail community-dwelling older adults in China
title_sort cognitive function in prefrail and frail community-dwelling older adults in china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391822/
https://www.ncbi.nlm.nih.gov/pubmed/30813907
http://dx.doi.org/10.1186/s12877-019-1056-8
work_keys_str_mv AT malina cognitivefunctioninprefrailandfrailcommunitydwellingolderadultsinchina
AT zhangli cognitivefunctioninprefrailandfrailcommunitydwellingolderadultsinchina
AT sunfei cognitivefunctioninprefrailandfrailcommunitydwellingolderadultsinchina
AT liyun cognitivefunctioninprefrailandfrailcommunitydwellingolderadultsinchina
AT tangzhe cognitivefunctioninprefrailandfrailcommunitydwellingolderadultsinchina