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Osteoblasts are “educated” by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment

INTRODUCTION: In a cancer-free environment in the adult, the skeleton continuously undergoes remodeling. Bone-resorbing osteoclasts excavate erosion cavities, and bone-depositing osteoblasts synthesize osteoid matrix that forms new bone, with no net bone gain or loss. When metastatic breast cancer c...

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Detalles Bibliográficos
Autores principales:	Kolb, Alexus D., Shupp, Alison B., Mukhopadhyay, Dimpi, Marini, Frank C., Bussard, Karen M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391840/ https://www.ncbi.nlm.nih.gov/pubmed/30813947 http://dx.doi.org/10.1186/s13058-019-1117-0

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