The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus

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Cytosolic DNA activates cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS), an innate immune sensor pivotal in anti-microbial defense, senescence, auto-immunity, and cancer. cGAS is considered to be a sequence-independent DNA sensor with limited access to nuclear DNA beca...

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Detalles Bibliográficos
Autores principales: Gentili, Matteo, Lahaye, Xavier, Nadalin, Francesca, Nader, Guilherme F.P., Puig Lombardi, Emilia, Herve, Solène, De Silva, Nilushi S., Rookhuizen, Derek C., Zueva, Elina, Goudot, Christel, Maurin, Mathieu, Bochnakian, Aurore, Amigorena, Sebastian, Piel, Matthieu, Fachinetti, Daniele, Londoño-Vallejo, Arturo, Manel, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391843/
https://www.ncbi.nlm.nih.gov/pubmed/30811988
http://dx.doi.org/10.1016/j.celrep.2019.01.105

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