Cargando…

The H(2)S-Releasing Naproxen Derivative ATB-346 and the Slow-Release H(2)S Donor GYY4137 Reduce Intestinal Inflammation and Restore Transit in Postoperative Ileus

Objective: Intestinal inflammation triggers postoperative ileus (POI), commonly seen after abdominal surgery and characterized by impaired gastrointestinal transit; when prolonged, this leads to increased morbidity. Hydrogen sulfide (H(2)S) is recognized as an important mediator of many (patho)physi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Van Dingenen, Jonas, Pieters, Leen, Vral, Anne, Lefebvre, Romain A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391894/ https://www.ncbi.nlm.nih.gov/pubmed/30842737 http://dx.doi.org/10.3389/fphar.2019.00116

Ejemplares similares

The H(2)S-releasing naproxen derivative, ATB-346, inhibits alveolar bone loss and inflammation in rats with ligature-induced periodontitis
por: Herrera, Bruno Schneider, et al.
Publicado: (2015)

GYY4137, an H(2)S Slow-Releasing Donor, Prevents Nitrative Stress and α-Synuclein Nitration in an MPTP Mouse Model of Parkinson’s Disease
por: Hou, Xiaoou, et al.
Publicado: (2017)

The Slow-Releasing Hydrogen Sulfide Donor, GYY4137, Exhibits Novel Anti-Cancer Effects In Vitro and In Vivo
por: Lee, Zheng Wei, et al.
Publicado: (2011)

Improved growth of pea, lettuce, and radish plants using the slow release of hydrogen sulfide from GYY-4137
por: Carter, Justin M., et al.
Publicado: (2018)

A New Slow Releasing, H(2)S Generating Compound, GYY4137 Relaxes Spontaneous and Oxytocin-Stimulated Contractions of Human and Rat Pregnant Myometrium
por: Robinson, Hayley, et al.
Publicado: (2012)

Vasoactive Effects of Chronic Treatment with Fructose and Slow-Releasing H(2)S Donor GYY-4137 in Spontaneously Hypertensive Rats: The Role of Nitroso and Sulfide Signalization
por: Berenyiova, Andrea, et al.
Publicado: (2022)

A H(2)S Donor GYY4137 Exacerbates Cisplatin-Induced Nephrotoxicity in Mice
por: Liu, Mi, et al.
Publicado: (2016)

The complex effects of the slow-releasing hydrogen sulfide donor GYY4137 in a model of acute joint inflammation and in human cartilage cells
por: Li, Ling, et al.
Publicado: (2013)

A comparative study on the anti-inflammatory effects of single oral doses of naproxen and its hydrogen sulfide (H(2)S)-releasing derivative ATB-346 in rats with carrageenan-induced synovitis
por: Ekundi-Valentim, Eduardo, et al.
Publicado: (2013)

Hydrogen Sulfide Donor GYY4137 Protects against Myocardial Fibrosis
por: Meng, Guoliang, et al.
Publicado: (2015)

Experimental research into the potential therapeutic effect of GYY4137 on Ovariectomy-induced osteoporosis
por: Xu, Zhong-Shi, et al.
Publicado: (2018)

Upregulation of Tolerogenic Pathways by the Hydrogen Sulfide Donor GYY4137 and Impaired Expression of H(2)S-Producing Enzymes in Multiple Sclerosis
por: Lazarević, Milica, et al.
Publicado: (2020)

The protective effects of GYY4137 on ipsilateral testicular injury in experimentally varicocele-induced rats
por: Ning, Jin-Zhuo, et al.
Publicado: (2018)

The Anxiolytic and Antidepressant Effects of Diallyl Disulfide and GYY4137 in Animals with Chronic Neuropathic Pain
por: Bai, Xue, et al.
Publicado: (2021)

Synthesis of Sulfur-35-Labeled Trisulfides and GYY-4137 as Donors of Radioactive Hydrogen Sulfide
por: Brown, Eric M., et al.
Publicado: (2023)

Hydrogen Sulfide Donor GYY4137 Rescues NRF2 Activation in Respiratory Syncytial Virus Infection
por: de Mello, Aline Haas, et al.
Publicado: (2022)

GYY4137 Attenuates Sodium Deoxycholate-Induced Intestinal Barrier Injury Both In Vitro and In Vivo
por: Chen, Zeyang, et al.
Publicado: (2019)

The H(2)S Donor GYY4137 Stimulates Reactive Oxygen Species Generation in BV2 Cells While Suppressing the Secretion of TNF and Nitric Oxide
por: Lazarević, Milica, et al.
Publicado: (2018)

GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats
por: Meng, Guoliang, et al.
Publicado: (2015)

GYY4137 Promotes Mice Feeding Behavior via Arcuate Nucleus Sulfur-Sulfhydrylation and AMPK Activation
por: Zhou, Jun, et al.
Publicado: (2018)

GYY4137 Regulates Extracellular Matrix Turnover in the Diabetic Kidney by Modulating Retinoid X Receptor Signaling
por: Juin, Subir Kumar, et al.
Publicado: (2021)

TRPA1 Ion Channel Determines Beneficial and Detrimental Effects of GYY4137 in Murine Serum-Transfer Arthritis
por: Bátai, István Z., et al.
Publicado: (2019)

Increased circulating peroxiredoxin-4 in sepsis model rats involves secretion from hepatocytes and is mitigated by GYY4137
por: Unuma, Kana, et al.
Publicado: (2019)

GYY4137 a H(2)S donor, attenuates ipsilateral epididymis injury in experimentally varicocele-induced rats via activation of the PI3K/Akt pathway
por: Xia, Yu-qi, et al.
Publicado: (2019)

GYY4137, a Hydrogen Sulfide Donor Modulates miR194-Dependent Collagen Realignment in Diabetic Kidney
por: John, AM Sashi Papu, et al.
Publicado: (2017)

GYY4137-Derived Hydrogen Sulfide Donates Electrons to the Mitochondrial Electron Transport Chain via Sulfide: Quinone Oxidoreductase in Endothelial Cells
por: Star, Bastiaan S., et al.
Publicado: (2023)

Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice
por: Campolo, Michela, et al.
Publicado: (2014)

GYY4137 and Sodium Hydrogen Sulfide Relaxations Are Inhibited by L-Cysteine and K(V)7 Channel Blockers in Rat Small Mesenteric Arteries
por: Abramavicius, Silvijus, et al.
Publicado: (2021)

Hydrogen sulfide donor GYY4137 suppresses proliferation of human colorectal cancer Caco-2 cells by inducing both cell cycle arrest and cell death
por: Sakuma, Satoru, et al.
Publicado: (2019)

The impact of viscosity on the dissolution of naproxen immediate-release tablets
por: Hassan, Dastan Salim, et al.
Publicado: (2022)

Gastrointestinal safety, chemotherapeutic potential, and classic pharmacological profile of NOSH‐naproxen (AVT‐219) a dual NO‐ and H(2)S‐releasing hybrid
por: Chattopadhyay, Mitali, et al.
Publicado: (2016)

Naproxen-Loaded Poly(2-hydroxyalkyl methacrylates): Preparation and Drug Release Dynamics
por: Aljubailah, Abeer, et al.
Publicado: (2022)

Encapsulation of Naproxen in Lipid-Based Matrix Microspheres: Characterization and Release Kinetics
por: Bhoyar, PK, et al.
Publicado: (2011)

Rapid releasing naproxen Liqui-Pellet using effervescent agent and neusilin US2
por: Lam, Matthew, et al.
Publicado: (2021)

Hydrogen Sulfide-Releasing Indomethacin-Derivative (ATB-344) Prevents the Development of Oxidative Gastric Mucosal Injuries
por: Głowacka, Urszula, et al.
Publicado: (2023)

Naproxen release behaviour from graphene oxide/cellulose acetate composite nanofibers
por: Purnamasari, Wulan, et al.
Publicado: (2022)

Macro- and Nanoscale Effect of Ethanol on Bovine Serum Albumin Gelation and Naproxen Release
por: Sanaeifar, Niuosha, et al.
Publicado: (2022)

Adsorption and Release Properties of Drug Delivery System Naproxen-SBA-15: Effect of Surface Polarity, Sodium/Acid Drug Form and pH
por: Zauška, Ľuboš, et al.
Publicado: (2022)

Sustained Release of Naproxen in a New Kind Delivery System of Carbon Nanotubes Hydrogel
por: Peng, Xiahui, et al.
Publicado: (2013)

Divergent effect of fast- and slow-releasing H(2)S donors on boar spermatozoa under oxidative stress
por: Pintus, Eliana, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_76fktaustr4p2tpmd7ekiqnpqs