Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages

Influenza vaccines targeting the highly conserved stem of the hemagglutinin (HA) surface glycoprotein have the potential to protect against pandemic and drifted seasonal influenza viruses not covered by current vaccines. While HA stem-based immunogens derived from group 1 influenza A viruses have be...

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Detalles Bibliográficos
Autores principales: Corbett, Kizzmekia S., Moin, Syed M., Yassine, Hadi M., Cagigi, Alberto, Kanekiyo, Masaru, Boyoglu-Barnum, Seyhan, Myers, Sky I., Tsybovsky, Yaroslav, Wheatley, Adam K., Schramm, Chaim A., Gillespie, Rebecca A., Shi, Wei, Wang, Lingshu, Zhang, Yi, Andrews, Sarah F., Joyce, M. Gordon, Crank, Michelle C., Douek, Daniel C., McDermott, Adrian B., Mascola, John R., Graham, Barney S., Boyington, Jeffrey C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391921/
https://www.ncbi.nlm.nih.gov/pubmed/30808695
http://dx.doi.org/10.1128/mBio.02810-18

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